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@ARTICLE{Vickery:836022,
      author       = {Vickery, Owen N and Machtens, Jan-Philipp and Zachariae,
                      Ulrich},
      title        = {{M}embrane potentials regulating {GPCR}s: insights from
                      experiments and molecular dynamics simulations},
      journal      = {Current opinion in pharmacology},
      volume       = {30},
      issn         = {1471-4892},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-05147},
      pages        = {44 - 50},
      year         = {2016},
      abstract     = {G-protein coupled receptors (GPCRs) form the largest class
                      of membrane proteins in humans and the targets of most
                      present drugs. Membrane potential is one of the defining
                      characteristics of living cells. Recent work has shown that
                      the membrane voltage, and changes thereof, modulates signal
                      transduction and ligand binding in GPCRs. As it may allow
                      differential signalling patterns depending on tissue, cell
                      type, and the excitation status of excitable cells, GPCR
                      voltage sensitivity could have important implications for
                      their pharmacology. This review summarises recent
                      experimental insights on GPCR voltage regulation and the
                      role of molecular dynamics simulations in identifying the
                      structural basis of GPCR voltage-sensing. We discuss the
                      potential significance for drug design on GPCR targets from
                      excitable and non-excitable cells.},
      cin          = {ICS-4},
      ddc          = {340},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000386861200009},
      pubmed       = {pmid:27474871},
      doi          = {10.1016/j.coph.2016.06.011},
      url          = {https://juser.fz-juelich.de/record/836022},
}