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@ARTICLE{Arrubla:836075,
author = {Arrubla, Jorge and Farrher, Ezequiel and Strippelmann,
Johanna and Tse, Desmond H. Y. and Grinberg, Farida and
Shah, N. J. and Neuner, Irene},
title = {{M}icrostructural and functional correlates of glutamate
concentration in the posterior cingulate cortex},
journal = {Journal of neuroscience research},
volume = {95},
number = {9},
issn = {0360-4012},
address = {New York, NY [u.a.]},
publisher = {Wiley-Liss},
reportid = {FZJ-2017-05199},
pages = {1796 - 1808},
year = {2017},
abstract = {Glutamate is the major excitatory neurotransmitter in the
human brain and has a central role in both intrinsic and
stimulus-induced activity. We conducted a study in a cohort
of healthy, male volunteers in which glutamate levels were
measured in the posterior cingulate cortex (PCC) using 1H
magnetic resonance spectroscopy at 3T. The advantages of
simultaneous electroencephalography and magnetic resonance
imaging (EEG-MRI) were exploited and the subjects were
measured in the same session and under the same
physiological conditions. Diffusion tensor imaging (DTI),
functional MRI (fMRI) and EEG were measured in order to
investigate the functional and microstructural correlates of
glutamate. The concentration of glutamate (institute units)
was calculated and those values were tested for correlation
with the metrics of resting state fMRI, DTI, and EEG
electrical sources. Our results showed that the
concentration of glutamate in the PCC had a significant
negative correlation with the tissue mean diffusivity in the
same area. The analysis of resting state networks did not
show any relationship between the concentration of glutamate
and the intrinsic activity of the resting state networks.
The concentration of glutamate showed a positive correlation
with the electrical generators of α–1 frequency and a
negative correlation with the generators of α–2 and
β–1 electrical generators. © 2017 Wiley Periodicals,
Inc.},
cin = {INM-4 / JARA-BRAIN},
ddc = {570},
cid = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
pnm = {573 - Neuroimaging (POF3-573)},
pid = {G:(DE-HGF)POF3-573},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000406930200008},
pubmed = {pmid:28117486},
doi = {10.1002/jnr.24010},
url = {https://juser.fz-juelich.de/record/836075},
}