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@ARTICLE{Popovych:836110,
      author       = {Popovych, Oleksandr and Lysyansky, Borys and Tass, Peter
                      A.},
      title        = {{C}losed-loop deep brain stimulation by pulsatile delayed
                      feedback with increased gap between pulse phases},
      journal      = {Scientific reports},
      volume       = {7},
      number       = {1},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2017-05234},
      pages        = {1033},
      year         = {2017},
      abstract     = {Computationally it was shown that desynchronizing delayed
                      feedback stimulation methods are effective closed-loop
                      techniques for the control of synchronization in ensembles
                      of interacting oscillators. We here computationally design
                      stimulation signals for electrical stimulation of neuronal
                      tissue that preserve the desynchronizing delayed feedback
                      characteristics and comply with mandatory charge
                      deposit-related safety requirements. For this, the amplitude
                      of the high-frequency (HF) train of biphasic charge-balanced
                      pulses used by the standard HF deep brain stimulation (DBS)
                      is modulated by the smooth feedback signals. In this way we
                      combine the desynchronizing delayed feedback approach with
                      the HF DBS technique. We show that such a pulsatile delayed
                      feedback stimulation can effectively and robustly
                      desynchronize a network of model neurons comprising
                      subthalamic nucleus and globus pallidus external and suggest
                      this approach for desynchronizing closed-loop DBS.
                      Intriguingly, an interphase gap introduced between the
                      recharging phases of the charge-balanced biphasic pulses can
                      significantly improve the stimulation-induced
                      desynchronization and reduce the amount of the administered
                      stimulation. In view of the recent experimental and clinical
                      studies indicating a superiority of the closed-loop DBS to
                      open-loop HF DBS, our results may contribute to a further
                      development of effective stimulation methods for the
                      treatment of neurological disorders characterized by
                      abnormal neuronal synchronization.},
      cin          = {INM-7},
      ddc          = {000},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28432303},
      UT           = {WOS:000399972900032},
      doi          = {10.1038/s41598-017-01067-x},
      url          = {https://juser.fz-juelich.de/record/836110},
}