TY  - JOUR
AU  - García-González, Diego
AU  - Khodosevich, Konstantin
AU  - Watanabe, Yasuhito
AU  - Rollenhagen, Astrid
AU  - Lübke, Joachim
AU  - Monyer, Hannah
TI  - Serotonergic Projections Govern Postnatal Neuroblast Migration
JO  - Neuron
VL  - 94
IS  - 3
SN  - 0896-6273
CY  - [Cambridge, Mass.]
PB  - Cell Press
M1  - FZJ-2017-05256
SP  - 534 - 549.e9
PY  - 2017
AB  - In many vertebrates, postnatally generated neurons often migrate long distances to reach their final destination, where they help shape local circuit activity. Concerted action of extrinsic stimuli is required to regulate long-distance migration. Some migratory principles are evolutionarily conserved, whereas others are species and cell type specific. Here we identified a serotonergic mechanism that governs migration of postnatally generated neurons in the mouse brain. Serotonergic axons originating from the raphe nuclei exhibit a conspicuous alignment with subventricular zone-derived neuroblasts. Optogenetic axonal activation provides functional evidence for serotonergic modulation of neuroblast migration. Furthermore, we show that the underlying mechanism involves serotonin receptor 3A (5HT3A)-mediated calcium influx. Thus, 5HT3A receptor deletion in neuroblasts impaired speed and directionality of migration and abolished calcium spikes. We speculate that serotonergic modulation of postnatally generated neuroblast migration is evolutionarily conserved as indicated by the presence of serotonergic axons in migratory paths in other vertebrates.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000400466700012
C6  - pmid:28472655
DO  - DOI:10.1016/j.neuron.2017.04.013
UR  - https://juser.fz-juelich.de/record/836133
ER  -