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@ARTICLE{GarcaGonzlez:836133,
      author       = {García-González, Diego and Khodosevich, Konstantin and
                      Watanabe, Yasuhito and Rollenhagen, Astrid and Lübke,
                      Joachim and Monyer, Hannah},
      title        = {{S}erotonergic {P}rojections {G}overn {P}ostnatal
                      {N}euroblast {M}igration},
      journal      = {Neuron},
      volume       = {94},
      number       = {3},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {FZJ-2017-05256},
      pages        = {534 - 549.e9},
      year         = {2017},
      abstract     = {In many vertebrates, postnatally generated neurons often
                      migrate long distances to reach their final destination,
                      where they help shape local circuit activity. Concerted
                      action of extrinsic stimuli is required to regulate
                      long-distance migration. Some migratory principles are
                      evolutionarily conserved, whereas others are species and
                      cell type specific. Here we identified a serotonergic
                      mechanism that governs migration of postnatally generated
                      neurons in the mouse brain. Serotonergic axons originating
                      from the raphe nuclei exhibit a conspicuous alignment with
                      subventricular zone-derived neuroblasts. Optogenetic axonal
                      activation provides functional evidence for serotonergic
                      modulation of neuroblast migration. Furthermore, we show
                      that the underlying mechanism involves serotonin receptor 3A
                      (5HT3A)-mediated calcium influx. Thus, 5HT3A receptor
                      deletion in neuroblasts impaired speed and directionality of
                      migration and abolished calcium spikes. We speculate that
                      serotonergic modulation of postnatally generated neuroblast
                      migration is evolutionarily conserved as indicated by the
                      presence of serotonergic axons in migratory paths in other
                      vertebrates.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000400466700012},
      pubmed       = {pmid:28472655},
      doi          = {10.1016/j.neuron.2017.04.013},
      url          = {https://juser.fz-juelich.de/record/836133},
}