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000836136 1001_ $$0P:(DE-HGF)0$$aRodriguez-Moreno, Javier$$b0
000836136 245__ $$aQuantitative 3D ultrastructure of synaptic boutons from the ‘lemniscal’ ventral posteromedial thalamic nucleus in mouse barrel cortex
000836136 260__ $$aOxford$$bOxford Univ. Press$$c2017
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000836136 520__ $$aThalamocortical synapses from “lemniscal” neurons of the dorsomedial portion of the rodent ventral posteromedial nucleus (VPMdm) are able to induce with remarkable efficacy, despite their relative low numbers, the firing of primary somatosensory cortex (S1) layer 4 (L4) neurons. To which extent this high efficacy depends on structural synaptic features remains unclear. Using both serial transmission (TEM) and focused ion beam milling scanning electron microscopy (FIB/SEM), we 3D-reconstructed and quantitatively analyzed anterogradely labeled VPMdm axons in L4 of adult mouse S1. All VPMdm synapses are asymmetric. Virtually all are established by axonal boutons, 53% of which contact multiple (2–4) elements (overall synapse/bouton ratio = 1.6). Most boutons are large (mean 0.47 μm3), and contain 1–3 mitochondria. Vesicle pools and postsynaptic density (PSD) surface areas are large compared to others in rodent cortex. Most PSDs are complex. Most synapses (83%) are established on dendritic spine heads. Furthermore, 15% of the postsynaptic spines receive a second, symmetric synapse. In addition, 13% of the spine heads have a large protrusion inserted into a membrane pouch of the VPMdm bouton. The unusual combination of structural features in VPMdm synapses is likely to contribute significantly to the high efficacy, strength, and plasticity of these thalamocortical synapses.
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000836136 7001_ $$0P:(DE-Juel1)131704$$aRollenhagen, Astrid$$b1
000836136 7001_ $$0P:(DE-HGF)0$$aArlandis, Jaime$$b2
000836136 7001_ $$0P:(DE-HGF)0$$aSantuy, Andrea$$b3
000836136 7001_ $$0P:(DE-HGF)0$$aMerchan-Pérez, Angel$$b4
000836136 7001_ $$0P:(DE-HGF)0$$aFelipe, Javier de$$b5
000836136 7001_ $$0P:(DE-Juel1)131696$$aLübke, Joachim$$b6
000836136 7001_ $$0P:(DE-HGF)0$$aClasca, Francisco$$b7$$eCorresponding author
000836136 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhx187$$p 1-17$$tCerebral cortex$$v $$x1047-3211$$y2017
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