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@ARTICLE{RodriguezMoreno:836136,
      author       = {Rodriguez-Moreno, Javier and Rollenhagen, Astrid and
                      Arlandis, Jaime and Santuy, Andrea and Merchan-Pérez, Angel
                      and Felipe, Javier de and Lübke, Joachim and Clasca,
                      Francisco},
      title        = {{Q}uantitative 3{D} ultrastructure of synaptic boutons from
                      the ‘lemniscal’ ventral posteromedial thalamic nucleus
                      in mouse barrel cortex},
      journal      = {Cerebral cortex},
      volume       = {},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2017-05259},
      pages        = {1-17},
      year         = {2017},
      note         = {Published: 28 July 2017},
      abstract     = {Thalamocortical synapses from “lemniscal” neurons of
                      the dorsomedial portion of the rodent ventral posteromedial
                      nucleus (VPMdm) are able to induce with remarkable efficacy,
                      despite their relative low numbers, the firing of primary
                      somatosensory cortex (S1) layer 4 (L4) neurons. To which
                      extent this high efficacy depends on structural synaptic
                      features remains unclear. Using both serial transmission
                      (TEM) and focused ion beam milling scanning electron
                      microscopy (FIB/SEM), we 3D-reconstructed and quantitatively
                      analyzed anterogradely labeled VPMdm axons in L4 of adult
                      mouse S1. All VPMdm synapses are asymmetric. Virtually all
                      are established by axonal boutons, $53\%$ of which contact
                      multiple (2–4) elements (overall synapse/bouton ratio =
                      1.6). Most boutons are large (mean 0.47 μm3), and contain
                      1–3 mitochondria. Vesicle pools and postsynaptic density
                      (PSD) surface areas are large compared to others in rodent
                      cortex. Most PSDs are complex. Most synapses $(83\%)$ are
                      established on dendritic spine heads. Furthermore, $15\%$ of
                      the postsynaptic spines receive a second, symmetric synapse.
                      In addition, $13\%$ of the spine heads have a large
                      protrusion inserted into a membrane pouch of the VPMdm
                      bouton. The unusual combination of structural features in
                      VPMdm synapses is likely to contribute significantly to the
                      high efficacy, strength, and plasticity of these
                      thalamocortical synapses.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28968773},
      UT           = {WOS:000443545600007},
      doi          = {10.1093/cercor/bhx187},
      url          = {https://juser.fz-juelich.de/record/836136},
}