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@ARTICLE{RodriguezMoreno:836136,
author = {Rodriguez-Moreno, Javier and Rollenhagen, Astrid and
Arlandis, Jaime and Santuy, Andrea and Merchan-Pérez, Angel
and Felipe, Javier de and Lübke, Joachim and Clasca,
Francisco},
title = {{Q}uantitative 3{D} ultrastructure of synaptic boutons from
the ‘lemniscal’ ventral posteromedial thalamic nucleus
in mouse barrel cortex},
journal = {Cerebral cortex},
volume = {},
issn = {1047-3211},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2017-05259},
pages = {1-17},
year = {2017},
note = {Published: 28 July 2017},
abstract = {Thalamocortical synapses from “lemniscal” neurons of
the dorsomedial portion of the rodent ventral posteromedial
nucleus (VPMdm) are able to induce with remarkable efficacy,
despite their relative low numbers, the firing of primary
somatosensory cortex (S1) layer 4 (L4) neurons. To which
extent this high efficacy depends on structural synaptic
features remains unclear. Using both serial transmission
(TEM) and focused ion beam milling scanning electron
microscopy (FIB/SEM), we 3D-reconstructed and quantitatively
analyzed anterogradely labeled VPMdm axons in L4 of adult
mouse S1. All VPMdm synapses are asymmetric. Virtually all
are established by axonal boutons, $53\%$ of which contact
multiple (2–4) elements (overall synapse/bouton ratio =
1.6). Most boutons are large (mean 0.47 μm3), and contain
1–3 mitochondria. Vesicle pools and postsynaptic density
(PSD) surface areas are large compared to others in rodent
cortex. Most PSDs are complex. Most synapses $(83\%)$ are
established on dendritic spine heads. Furthermore, $15\%$ of
the postsynaptic spines receive a second, symmetric synapse.
In addition, $13\%$ of the spine heads have a large
protrusion inserted into a membrane pouch of the VPMdm
bouton. The unusual combination of structural features in
VPMdm synapses is likely to contribute significantly to the
high efficacy, strength, and plasticity of these
thalamocortical synapses.},
cin = {INM-2},
ddc = {610},
cid = {I:(DE-Juel1)INM-2-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28968773},
UT = {WOS:000443545600007},
doi = {10.1093/cercor/bhx187},
url = {https://juser.fz-juelich.de/record/836136},
}