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@ARTICLE{Komorowski:836173,
      author       = {Komorowski, A. and James, G. M. and Phillipe, C. and
                      Gryglewski, G. and Bauer, Andreas and Hienert, M. and Spies,
                      M. and Kautzky, A. and Vanicek, T. and Hahn, A. and
                      Traub-Weidinger, T. and Winkler, D. and Wadsak, W. and
                      Mitterhauser, M. and Hacker, M. and Kasper, S. and
                      Lanzenberger, R.},
      title        = {{A}ssociation of {P}rotein {D}istribution and
                      {G}ene{E}xpression {R}evealed by {PET} and
                      {P}ost-{M}ortem{Q}uantification in the {S}erotonergic
                      {S}ystem of the{H}uman {B}rain},
      journal      = {Cerebral cortex},
      volume       = {27},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2017-05296},
      pages        = {117-130},
      year         = {2017},
      abstract     = {Regional differences in posttranscriptional mechanisms may
                      influence in vivo protein densities. The association of
                      positron emission tomography (PET) imaging data from 112
                      healthy controls and gene expression values from the Allen
                      Human Brain Atlas, based on post-mortem brains, was
                      investigated for key serotonergic proteins. PET binding
                      values and gene expression intensities were correlated for
                      the main inhibitory (5-HT1A) and excitatory (5-HT2A)
                      serotonin receptor, the serotonin transporter (SERT) as well
                      as monoamine oxidase-A (MAO-A), using Spearman's correlation
                      coefficients (rs) in a voxel-wise and region-wise analysis.
                      Correlations indicated a strong linear relationship between
                      gene and protein expression for both the 5-HT1A (voxel-wise
                      rs = 0.71; region-wise rs = 0.93) and the 5-HT2A receptor
                      (rs = 0.66; 0.75), but only a weak association for MAO-A (rs
                      = 0.26; 0.66) and no clear correlation for SERT (rs = 0.17;
                      0.29). Additionally, region-wise correlations were performed
                      using mRNA expression from the HBT, yielding comparable
                      results (5-HT1Ars = 0.82; 5-HT2Ars = 0.88; MAO-A rs = 0.50;
                      SERT rs = −0.01). The SERT and MAO-A appear to be
                      regulated in a region-specific manner across the whole
                      brain. In contrast, the serotonin-1A and -2A receptors are
                      presumably targeted by common posttranscriptional processes
                      similar in all brain areas suggesting the applicability of
                      mRNA expression as surrogate parameter for density of these
                      proteins.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000397064800011},
      pubmed       = {pmid:27909009},
      doi          = {10.1093/cercor/bhw355},
      url          = {https://juser.fz-juelich.de/record/836173},
}