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@ARTICLE{Volz:836406,
      author       = {Volz, L. J. and Vollmer, M. and Michely, J. and Fink, G. R.
                      and Rothwell, J. C. and Grefkes, C.},
      title        = {{T}ime-dependent functional role of the contralesional
                      motor cortex after stroke},
      journal      = {NeuroImage: Clinical},
      volume       = {16},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-05527},
      pages        = {165 - 174},
      year         = {2017},
      abstract     = {After stroke, movements of the paretic hand rely on altered
                      motor network dynamics typically including additional
                      activation of the contralesional primary motor cortex (M1).
                      The functional implications of contralesional M1 recruitment
                      to date remain a matter of debate.We here assessed the role
                      of contralesional M1 in 12 patients recovering from a
                      first-ever stroke using online transcranial magnetic
                      stimulation (TMS): Short bursts of TMS were administered
                      over contralesional M1 or a control site (occipital vertex)
                      while patients performed different motor tasks with their
                      stroke-affected hand.In the early subacute phase (1–2
                      weeks post-stroke), we observed significant improvements in
                      maximum finger tapping frequency when interfering with
                      contralesional M1, while maximum grip strength and speeded
                      movement initiation remained unaffected. After > 3 months of
                      motor recovery, disruption of contralesional M1 activity did
                      not interfere with performance in any of the three tasks,
                      similar to what we observed in healthy controls.In patients
                      with mild to moderate motor deficits, contralesional M1 has
                      a task- and time-specific negative influence on motor
                      performance of the stroke-affected hand. Our results help to
                      explain previous contradicting findings on the role of
                      contralesional M1 in recovery of function.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28794977},
      UT           = {WOS:000413235100018},
      doi          = {10.1016/j.nicl.2017.07.024},
      url          = {https://juser.fz-juelich.de/record/836406},
}