TY  - JOUR
AU  - Muharini, Rini
AU  - Díaz, Adriana
AU  - Ebrahim, Weaam
AU  - Mándi, Attila
AU  - Kurtán, Tibor
AU  - Rehberg, Nidja
AU  - Kalscheuer, Rainer
AU  - Hartmann, Rudolf
AU  - Orfali, Raha S.
AU  - Lin, Wenhan
AU  - Liu, Zhen
AU  - Proksch, Peter
TI  - Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa
JO  - Journal of natural products
VL  - 80
IS  - 1
SN  - 0163-3864
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2017-05549
SP  - 169–180
PY  - 2017
AB  - Fourteen new natural products, namely, 2-[(Z)-styryl]-5-geranylresorcin-1-carboxylic acid (1), amorfrutin D (2), 4-O-demethylamorfrutin D (3), 8-geranyl-3,5,7-trihydroxyflavanone (4), 8-geranyl-5,7,3′-trihydroxy-4′-methoxyisoflavone (5), 6-geranyl-5,7,3′-trihydroxy-4′-methoxyisoflavone (6), 8-geranyl-7,3′-dihydroxy-4′-methoxyisoflavone (7), 3-O-demethyldalbinol (8), 6a,12a-dehydro-3-O-demethylamorphigenin (9), (6aR,12aR,5′R)-amorphigenin (10), amorphispironones B and C (11 and 12), resokaempferol 3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside-7-O-α-l-rhamnopyranoside (13), and daidzein 7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (14), together with 40 known compounds, were isolated from the fruits of Amorpha fruticosa. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic analysis as well as from the mass spectrometry data. ECD calculations were performed to determine the absolute configurations of 11 and 15. Compounds 1, 4–6, and 16–23 showed potent to moderate antibacterial activities against several Gram-positive bacteria with MIC values ranging from 3.1 to 100 μM. In addition, compounds 11 and 24–33 were significantly cytotoxic against the L5178Y mouse lymphoma cell line and exhibited IC50 values from 0.2 to 10.2 μM.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000393089600023
C6  - pmid:28075580
DO  - DOI:10.1021/acs.jnatprod.6b00809
UR  - https://juser.fz-juelich.de/record/836428
ER  -