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@ARTICLE{Muharini:836428,
author = {Muharini, Rini and Díaz, Adriana and Ebrahim, Weaam and
Mándi, Attila and Kurtán, Tibor and Rehberg, Nidja and
Kalscheuer, Rainer and Hartmann, Rudolf and Orfali, Raha S.
and Lin, Wenhan and Liu, Zhen and Proksch, Peter},
title = {{A}ntibacterial and {C}ytotoxic {P}henolic {M}etabolites
from the {F}ruits of {A}morpha fruticosa},
journal = {Journal of natural products},
volume = {80},
number = {1},
issn = {0163-3864},
address = {Washington, DC},
publisher = {Soc.},
reportid = {FZJ-2017-05549},
pages = {169–180},
year = {2017},
abstract = {Fourteen new natural products, namely,
2-[(Z)-styryl]-5-geranylresorcin-1-carboxylic acid (1),
amorfrutin D (2), 4-O-demethylamorfrutin D (3),
8-geranyl-3,5,7-trihydroxyflavanone (4),
8-geranyl-5,7,3′-trihydroxy-4′-methoxyisoflavone (5),
6-geranyl-5,7,3′-trihydroxy-4′-methoxyisoflavone (6),
8-geranyl-7,3′-dihydroxy-4′-methoxyisoflavone (7),
3-O-demethyldalbinol (8),
6a,12a-dehydro-3-O-demethylamorphigenin (9),
(6aR,12aR,5′R)-amorphigenin (10), amorphispironones B and
C (11 and 12), resokaempferol
3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside-7-O-α-l-rhamnopyranoside
(13), and daidzein
7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (14),
together with 40 known compounds, were isolated from the
fruits of Amorpha fruticosa. The structures of the new
compounds were elucidated by 1D and 2D NMR spectroscopic
analysis as well as from the mass spectrometry data. ECD
calculations were performed to determine the absolute
configurations of 11 and 15. Compounds 1, 4–6, and 16–23
showed potent to moderate antibacterial activities against
several Gram-positive bacteria with MIC values ranging from
3.1 to 100 μM. In addition, compounds 11 and 24–33 were
significantly cytotoxic against the L5178Y mouse lymphoma
cell line and exhibited IC50 values from 0.2 to 10.2 μM.},
cin = {ICS-6},
ddc = {500},
cid = {I:(DE-Juel1)ICS-6-20110106},
pnm = {551 - Functional Macromolecules and Complexes (POF3-551)},
pid = {G:(DE-HGF)POF3-551},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000393089600023},
pubmed = {pmid:28075580},
doi = {10.1021/acs.jnatprod.6b00809},
url = {https://juser.fz-juelich.de/record/836428},
}