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@ARTICLE{Sheng:836751,
      author       = {Sheng, Yingjie and Beguin, Estelle and Nesbitt, Heather and
                      Kamila, Sukanta and Owen, Joshua and Barnsley, Lester and
                      Callan, Bridgeen and O'Kane, Christopher and Nomikou,
                      Nikolitsa and Hamoudi, Rifat and Taylor, Mark A. and Love,
                      Mark and Kelly, Paul and O'Rourke, Declan and Stride,
                      Eleanor and McHale, Anthony P. and Callan, John F.},
      title        = {{M}agnetically responsive microbubbles as delivery vehicles
                      for targeted sonodynamic and antimetabolite therapy of
                      pancreatic cancer},
      journal      = {Journal of controlled release},
      volume       = {262},
      issn         = {0168-3659},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-05804},
      pages        = {192 - 200},
      year         = {2017},
      abstract     = {Magnetically responsive microbubbles (MagMBs), consisting
                      of an oxygen gas core and a phospholipid coating
                      functionalised with Rose Bengal (RB) and/or 5-fluorouracil
                      (5-FU), were assessed as a delivery vehicle for the targeted
                      treatment of pancreatic cancer using combined antimetabolite
                      and sonodynamic therapy (SDT). MagMBs delivering the
                      combined 5-FU/SDT treatment produced a reduction in cell
                      viability of over $50\%$ when tested against a panel of four
                      pancreatic cancer cell lines in vitro. Intravenous
                      administration of the MagMBs to mice bearing orthotopic
                      human xenograft BxPC-3 tumours yielded a $48.3\%$ reduction
                      in tumour volume relative to an untreated control group (p <
                      0.05) when the tumour was exposed to both external magnetic
                      and ultrasound fields during administration of the MagMBs.
                      In contrast, application of an external ultrasound field
                      alone resulted in a $27\%$ reduction in tumour volume. In
                      addition, activated caspase and BAX protein levels were both
                      observed to be significantly elevated in tumours harvested
                      from animals treated with the MagMBs in the presence of
                      magnetic and ultrasonic fields when compared to expression
                      of those proteins in tumours from either the control or
                      ultrasound field only groups (p < 0.05). These results
                      suggest MagMBs have considerable potential as a platform to
                      enable the targeted delivery of combined
                      sonodynamic/antimetabolite therapy in pancreatic cancer.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28764995},
      UT           = {WOS:000411201100019},
      doi          = {10.1016/j.jconrel.2017.07.040},
      url          = {https://juser.fz-juelich.de/record/836751},
}