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@ARTICLE{BrkerLai:836931,
      author       = {Bröker‐Lai, Jenny and Kollewe, Astrid and
                      Schindeldecker, Barbara and Pohle, Jörg and Nguyen Chi,
                      Vivan and Mathar, Ilka and Guzman, Raul and Schwarz, Yvonne
                      and Lai, Alan and Weißgerber, Petra and Schwegler, Herbert
                      and Dietrich, Alexander and Both, Martin and Sprengel, Rolf
                      and Draguhn, Andreas and Köhr, Georg and Fakler, Bernd and
                      Flockerzi, Veit and Bruns, Dieter and Freichel, Marc},
      title        = {{H}eteromeric channels formed by {TRPC}1, {TRPC}4 and
                      {TRPC}5 define hippocampal synaptic transmission and working
                      memory},
      journal      = {The EMBO journal},
      volume       = {36},
      issn         = {1460-2075},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {FZJ-2017-05957},
      pages        = {e201696369 -},
      year         = {2017},
      abstract     = {Canonical transient receptor potential (TRPC) channels
                      influence various neuronal functions. Using quantitative
                      high‐resolution mass spectrometry, we demonstrate that
                      TRPC1, TRPC4, and TRPC5 assemble into heteromultimers with
                      each other, but not with other TRP family members in the
                      mouse brain and hippocampus. In hippocampal neurons from
                      Trpc1/Trpc4/Trpc5‐triple‐knockout (Trpc1/4/5−/−)
                      mice, lacking any TRPC1‐, TRPC4‐, or TRPC5‐containing
                      channels, action potential‐triggered excitatory
                      postsynaptic currents (EPSCs) were significantly reduced,
                      whereas frequency, amplitude, and kinetics of quantal
                      miniature EPSC signaling remained unchanged. Likewise,
                      evoked postsynaptic responses in hippocampal slice
                      recordings and transient potentiation after tetanic
                      stimulation were decreased. In vivo, Trpc1/4/5−/− mice
                      displayed impaired cross‐frequency coupling in hippocampal
                      networks and deficits in spatial working memory, while
                      spatial reference memory was unaltered. Trpc1/4/5−/−
                      animals also exhibited deficiencies in adapting to a new
                      challenge in a relearning task. Our results indicate the
                      contribution of heteromultimeric channels from TRPC1, TRPC4,
                      and TRPC5 subunits to the regulation of mechanisms
                      underlying spatial working memory and flexible relearning by
                      facilitating proper synaptic transmission in hippocampal
                      neurons.},
      cin          = {ICS-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000410763900011},
      pubmed       = {pmid:28790178},
      doi          = {10.15252/embj.201696369},
      url          = {https://juser.fz-juelich.de/record/836931},
}