% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Filss:836953,
      author       = {Filss, Christian and Albert, Nathalie L. and Böning, Guido
                      and Rota Kops, Elena and Suchorska, Bogdana and Stoffels,
                      Gabriele and Galldiks, Norbert and Shah, Nadim J. and
                      Mottaghy, Felix M. and Bartenstein, Peter and Tonn, Jörg C.
                      and Langen, Karl-Josef},
      title        = {{O}-(2-[$^{18}${F}]fluoroethyl)-l-tyrosine {PET} in
                      gliomas: influence of data processing in different centres},
      journal      = {EJNMMI Research},
      volume       = {7},
      number       = {1},
      issn         = {2191-219X},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2017-05975},
      pages        = {64},
      year         = {2017},
      abstract     = {BackgroundPET using O-(2-[18F]fluoroethyl)-l-tyrosine
                      (18F-FET) is an established method for brain tumour
                      diagnostics, but data processing varies in different
                      centres. This study analyses the influence of methodological
                      differences between two centres for tumour characterization
                      with 18F-FET PET using the same PET scanner.Methodological
                      differences between centres A and B in the evaluation of
                      18F-FET PET data were identified for (1) framing of PET
                      dynamic data, (2) data reconstruction, (3) cut-off values
                      for tumour delineation to determine tumour-to-brain ratios
                      (TBR) and tumour volume (Tvol) and (4) ROI definition to
                      determine time activity curves (TACs) in the tumour. Based
                      on the 18F-FET PET data of 40 patients with untreated
                      cerebral gliomas (20 WHO grade II, 10 WHO grade III, 10 WHO
                      grade IV), the effect of different data processing in the
                      two centres on TBRmean, TBRmax, Tvol, time-to-peak (TTP) and
                      slope of the TAC was compared. Further, the effect on tumour
                      grading was evaluated by ROC analysis.ResultsSignificant
                      differences between centres A and B were found especially
                      for TBRmax (2.84 ± 0.99 versus 3.34 ± 1.13; p < 0.001),
                      Tvol (1.14 ± 1.28 versus 1.51 ± 1.44; p < 0.001) and TTP
                      (22.4 ± 8.3 min versus 30.8 ± 6.3 min; p < 0.001) and
                      minor differences for TBRmean and slope. Tumour grading was
                      not influenced by different data
                      processing.ConclusionsVariable data processing of 18F-FET
                      PET in different centres leads to significant differences
                      especially for TBRmax and Tvol. A standardization of data
                      processing and evaluation is needed to make 18F-FET PET
                      comparable between different centres.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000407811100002},
      doi          = {10.1186/s13550-017-0316-x},
      url          = {https://juser.fz-juelich.de/record/836953},
}