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@ARTICLE{Achilles:837067,
      author       = {Achilles, Elisabeth and Weiss-Blankenhorn, Peter and Fink,
                      Gereon R. and Binder, Ellen and Price, Cathy J. and Hope,
                      Thomas M. H.},
      title        = {{U}sing multi-level {B}ayesian lesion-symptom mapping to
                      probe the body-part-specificity of gesture imitation skills},
      journal      = {NeuroImage},
      volume       = {161},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2017-06076},
      pages        = {94 - 103},
      year         = {2017},
      abstract     = {Past attempts to identify the neural substrates of hand and
                      finger imitation skills in the left hemisphere of the brain
                      have yielded inconsistent results. Here, we analyse those
                      associations in a large sample of 257 left hemisphere stroke
                      patients. By introducing novel Bayesian methods, we
                      characterise lesion symptom associations at three levels:
                      the voxel-level, the single-region level (using anatomically
                      defined regions), and the region-pair level. The results are
                      inconsistent across those three levels and we argue that
                      each level of analysis makes assumptions which constrain the
                      results it can produce. Regardless of the inconsistencies
                      across levels, and contrary to past studies which implicated
                      differential neural substrates for hand and finger
                      imitation, we find no consistent voxels or regions, where
                      damage affects one imitation skill and not the other, at any
                      of the three analysis levels. Our novel Bayesian approach
                      indicates that any apparent differences appear to be driven
                      by an increased sensitivity of hand imitation skills to
                      lesions that also impair finger imitation. In our analyses,
                      the results of the highest level of analysis (region-pairs)
                      emphasise a role of the primary somatosensory and motor
                      cortices, and the occipital lobe in imitation. We argue that
                      this emphasis supports an account of both imitation tasks
                      based on direct sensor-motor connections, which throws doubt
                      on past accounts which imply the need for an intermediate
                      (e.g. body-part-coding) system of representation.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28822751},
      UT           = {WOS:000415673100009},
      doi          = {10.1016/j.neuroimage.2017.08.036},
      url          = {https://juser.fz-juelich.de/record/837067},
}