TY - JOUR
AU - Verger, Antoine
AU - Filss, Christian
AU - Lohmann, Philipp
AU - Stoffels, Gabriele
AU - Sabel, Michael
AU - Wittsack, Hans J.
AU - Rota Kops, Elena
AU - Galldiks, Norbert
AU - Fink, Gereon R.
AU - Shah, Nadim J.
AU - Langen, Karl-Josef
TI - Comparison of $^{18}$F-FET PET and perfusion-weighted MRI for glioma grading: a hybrid PET/MR study
JO - European journal of nuclear medicine and molecular imaging
VL - 44
IS - 13
SN - 1619-7089
CY - Heidelberg [u.a.]
PB - Springer-Verl.
M1 - FZJ-2017-06078
SP - 2257–2265
PY - 2017
AB - PurposeBoth perfusion-weighted MR imaging (PWI) and O-(2-18F-fluoroethyl)-L-tyrosine PET (18F–FET) provide grading information in cerebral gliomas. The aim of this study was to compare the diagnostic value of 18F–FET PET and PWI for tumor grading in a series of patients with newly diagnosed, untreated gliomas using an integrated PET/MR scanner.MethodsSeventy-two patients with untreated gliomas [22 low-grade gliomas (LGG), and 50 high-grade gliomas (HGG)] were investigated with 18F–FET PET and PWI using a hybrid PET/MR scanner. After visual inspection of PET and PWI maps (rCBV, rCBF, MTT), volumes of interest (VOIs) with a diameter of 16 mm were centered upon the maximum of abnormality in the tumor area in each modality and the contralateral unaffected hemisphere. Mean and maximum tumor-to-brain ratios (TBRmean, TBRmax) were calculated. In addition, Time-to-Peak (TTP) and slopes of time–activity curves were calculated for 18F–FET PET. Diagnostic accuracies of 18F–FET PET and PWI for differentiating low-grade glioma (LGG) from high-grade glioma (HGG) were evaluated by receiver operating characteristic analyses (area under the curve; AUC).ResultsThe diagnostic accuracy of 18F–FET PET and PWI to discriminate LGG from HGG was similar with highest AUC values for TBRmean and TBRmax of 18F–FET PET uptake (0.80, 0.83) and for TBRmean and TBRmax of rCBV (0.80, 0.81). In case of increased signal in the tumor area with both methods (n = 32), local hot-spots were incongruent in 25 patients (78%) with a mean distance of 10.6 ± 9.5 mm. Dynamic FET PET and combination of different parameters did not further improve diagnostic accuracy.ConclusionsBoth 18F–FET PET and PWI discriminate LGG from HGG with similar diagnostic performance. Regional abnormalities in the tumor area are usually not congruent indicating that tumor grading by 18F–FET PET and PWI is based on different pathophysiological phenomena.
LB - PUB:(DE-HGF)16
C6 - pmid:28831534
UR - <Go to ISI:>//WOS:000415085500013
DO - DOI:10.1007/s00259-017-3812-3
UR - https://juser.fz-juelich.de/record/837081
ER -