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@ARTICLE{Verger:837081,
      author       = {Verger, Antoine and Filss, Christian and Lohmann, Philipp
                      and Stoffels, Gabriele and Sabel, Michael and Wittsack, Hans
                      J. and Rota Kops, Elena and Galldiks, Norbert and Fink,
                      Gereon R. and Shah, Nadim J. and Langen, Karl-Josef},
      title        = {{C}omparison of $^{18}${F}-{FET} {PET} and
                      perfusion-weighted {MRI} for glioma grading: a hybrid
                      {PET}/{MR} study},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {44},
      number       = {13},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2017-06078},
      pages        = {2257–2265},
      year         = {2017},
      abstract     = {PurposeBoth perfusion-weighted MR imaging (PWI) and
                      O-(2-18F-fluoroethyl)-L-tyrosine PET (18F–FET) provide
                      grading information in cerebral gliomas. The aim of this
                      study was to compare the diagnostic value of 18F–FET PET
                      and PWI for tumor grading in a series of patients with newly
                      diagnosed, untreated gliomas using an integrated PET/MR
                      scanner.MethodsSeventy-two patients with untreated gliomas
                      [22 low-grade gliomas (LGG), and 50 high-grade gliomas
                      (HGG)] were investigated with 18F–FET PET and PWI using a
                      hybrid PET/MR scanner. After visual inspection of PET and
                      PWI maps (rCBV, rCBF, MTT), volumes of interest (VOIs) with
                      a diameter of 16 mm were centered upon the maximum of
                      abnormality in the tumor area in each modality and the
                      contralateral unaffected hemisphere. Mean and maximum
                      tumor-to-brain ratios (TBRmean, TBRmax) were calculated. In
                      addition, Time-to-Peak (TTP) and slopes of time–activity
                      curves were calculated for 18F–FET PET. Diagnostic
                      accuracies of 18F–FET PET and PWI for differentiating
                      low-grade glioma (LGG) from high-grade glioma (HGG) were
                      evaluated by receiver operating characteristic analyses
                      (area under the curve; AUC).ResultsThe diagnostic accuracy
                      of 18F–FET PET and PWI to discriminate LGG from HGG was
                      similar with highest AUC values for TBRmean and TBRmax of
                      18F–FET PET uptake (0.80, 0.83) and for TBRmean and TBRmax
                      of rCBV (0.80, 0.81). In case of increased signal in the
                      tumor area with both methods (n = 32), local hot-spots were
                      incongruent in 25 patients $(78\%)$ with a mean distance of
                      10.6 ± 9.5 mm. Dynamic FET PET and combination of different
                      parameters did not further improve diagnostic
                      accuracy.ConclusionsBoth 18F–FET PET and PWI discriminate
                      LGG from HGG with similar diagnostic performance. Regional
                      abnormalities in the tumor area are usually not congruent
                      indicating that tumor grading by 18F–FET PET and PWI is
                      based on different pathophysiological phenomena.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28831534},
      UT           = {WOS:000415085500013},
      doi          = {10.1007/s00259-017-3812-3},
      url          = {https://juser.fz-juelich.de/record/837081},
}