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@ARTICLE{Malter:837084,
      author       = {Malter, M. P. and Nass, R. D. and Kaluschke, T. and Fink,
                      G. R. and Burghaus, L. and Dohmen, C.},
      title        = {{N}ew onset status epilepticus in older patients: clinical
                      characteristics and outcome},
      journal      = {Seizure},
      volume       = {51},
      number       = {},
      issn         = {1059-1311},
      address      = {Oxford [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-06081},
      pages        = {114-120},
      year         = {2017},
      abstract     = {PurposeWe here evaluated (1) the differential
                      characteristics of status epilepticus (SE) in older (≥60
                      years) compared to younger adults (18–59 years). In
                      particular, we were interested in (2) the proportion and
                      characteristics of new onset SE in patients with no history
                      of epilepsy (NOSE) in older compared to younger adults, and
                      (3) predictive parameters for clinical outcome in older
                      subjects with NOSE.MethodsWe performed a monocentric
                      retrospective analysis of all adult patients (≥18 years)
                      admitted with SE to our tertiary care centre over a period
                      of 10 years (2006–2015) to evaluate clinical
                      characteristics and short-time outcome at
                      discharge.ResultsOne-hundred-thirty-five patients with SE
                      were included in the study. Mean age at onset was 64 years
                      (range 21–90), eighty-seven of the patients $(64\%)$ were
                      older than 60 years. In 76 patients $(56\%),$ SE occurred as
                      NOSE, sixty-seven percent of them were aged ≥60 years.
                      There was no age-dependent predominance for NOSE. NOSE was
                      not a relevant outcome predictor, especially regarding
                      age-related subgroups. Older patients with NOSE had less
                      frequently general tonic clonic SE (GTCSE; p = 0.001) and
                      were more often female (p = 0.01). Regarding outcome
                      parameters and risk factors in older patients with NOSE,
                      unfavourable outcome was associated with infections during
                      in-hospital treatment (0.04), extended stay in ICU (p =
                      0.001), and generally in hospital (p < 0.001).ConclusionIn
                      our cohort, older patients represented the predominant
                      subgroup in patients with SE. Older patients suffered more
                      often from non-convulsive semiology and had a less
                      favourable short-time outcome. NOSE was not a predictive
                      outcome parameter in older patients. Data suggest that
                      avoiding infections should have a priority because higher
                      infection rates were associated with unfavourable outcome.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28843069},
      UT           = {WOS:000414110900020},
      doi          = {10.1016/j.seizure.2017.08.006},
      url          = {https://juser.fz-juelich.de/record/837084},
}