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000837123 1001_ $$0P:(DE-HGF)0$$aFigueroa-Miranda, Gabriela$$b0
000837123 245__ $$aAptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability
000837123 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2018
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000837123 520__ $$aMalaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.
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000837123 7001_ $$0P:(DE-Juel1)157885$$aFeng, Lingyan$$b1
000837123 7001_ $$0P:(DE-HGF)0$$aShiu, Simon Chi-Chin$$b2
000837123 7001_ $$0P:(DE-HGF)0$$aDirkzwager, Roderick Marshall$$b3
000837123 7001_ $$0P:(DE-HGF)0$$aCheung, Yee-Wai$$b4
000837123 7001_ $$0P:(DE-HGF)0$$aTanner, Julian Alexander$$b5
000837123 7001_ $$0P:(DE-HGF)0$$aSchöning, Michael Josef$$b6
000837123 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b7$$ufzj
000837123 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b8$$eCorresponding author$$ufzj
000837123 773__ $$0PERI:(DE-600)1500731-5$$a10.1016/j.snb.2017.07.117$$gVol. 255, p. 235 - 243$$p235 - 243$$tSensors and actuators <Lausanne> / B$$v255$$x0925-4005$$y2018
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