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@ARTICLE{FigueroaMiranda:837123,
      author       = {Figueroa-Miranda, Gabriela and Feng, Lingyan and Shiu,
                      Simon Chi-Chin and Dirkzwager, Roderick Marshall and Cheung,
                      Yee-Wai and Tanner, Julian Alexander and Schöning, Michael
                      Josef and Offenhäusser, Andreas and Mayer, Dirk},
      title        = {{A}ptamer-based electrochemical biosensor for highly
                      sensitive and selective malaria detection with adjustable
                      dynamic response range and reusability},
      journal      = {Sensors and actuators / B},
      volume       = {255},
      issn         = {0925-4005},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-06112},
      pages        = {235 - 243},
      year         = {2018},
      abstract     = {Malaria infection remains a significant risk for much of
                      the population of tropical and subtropical areas,
                      particularly in developing countries. Therefore, it is of
                      high importance to develop sensitive, accurate and
                      inexpensive malaria diagnosis tests. Here, we present a
                      novel aptamer-based electrochemical biosensor (aptasensor)
                      for malaria detection by impedance spectroscopy, through the
                      specific recognition between a highly discriminatory DNA
                      aptamer and its target Plasmodium falciparum lactate
                      dehydrogenase (PfLDH). Interestingly, due to the isoelectric
                      point (pI) of PfLDH, the aptasensor response showed an
                      adjustable detection range based on the different protein
                      net-charge at variable pH environments. The specific aptamer
                      recognition allows sensitive protein detection with an
                      expanded detection range and a low detection limit, as well
                      as a high specificity for PfLDH compared to analogous
                      proteins. The specific feasibility of the aptasensor is
                      further demonstrated by detection of the target PfLDH in
                      human serum. Furthermore, the aptasensor can be easily
                      regenerated and thus applied for multiple usages. The
                      robustness, sensitivity, and reusability of the presented
                      aptasensor make it a promising candidate for point-of-care
                      diagnostic systems.},
      cin          = {ICS-8},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000414151800028},
      doi          = {10.1016/j.snb.2017.07.117},
      url          = {https://juser.fz-juelich.de/record/837123},
}