%0 Journal Article
%A Mauler, Jörg
%A Maudsley, Andrew A.
%A Langen, Karl-Josef
%A Nikoubashman, Omid
%A Stoffels, Gabriele
%A Sheriff, Sulaiman
%A Lohmann, Philipp
%A Filss, Christian
%A Galldiks, Norbert
%A Rota Kops, Elena
%A Shah, N. J.
%T Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study
%J Journal of nuclear medicine
%V 59
%N 4
%@ 2159-662X
%C New York, NY
%I Soc.
%M FZJ-2017-06351
%P 603-609
%D 2018
%X PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and may represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28848036
%U <Go to ISI:>//WOS:000428981100021
%R 10.2967/jnumed.117.196709
%U https://juser.fz-juelich.de/record/837426