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000837426 1001_ $$0P:(DE-Juel1)144215$$aMauler, Jörg$$b0$$eCorresponding author$$ufzj
000837426 245__ $$aSpatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study
000837426 260__ $$aNew York, NY$$bSoc.$$c2018
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000837426 520__ $$aPET imaging of amino acid transport using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and may represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.
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000837426 7001_ $$0P:(DE-HGF)0$$aMaudsley, Andrew A.$$b1
000837426 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b2$$ufzj
000837426 7001_ $$0P:(DE-Juel1)162385$$aNikoubashman, Omid$$b3
000837426 7001_ $$0P:(DE-Juel1)131627$$aStoffels, Gabriele$$b4$$ufzj
000837426 7001_ $$0P:(DE-HGF)0$$aSheriff, Sulaiman$$b5
000837426 7001_ $$0P:(DE-Juel1)145110$$aLohmann, Philipp$$b6$$ufzj
000837426 7001_ $$0P:(DE-Juel1)141877$$aFilss, Christian$$b7$$ufzj
000837426 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b8$$ufzj
000837426 7001_ $$0P:(DE-Juel1)131788$$aRota Kops, Elena$$b9$$ufzj
000837426 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b10$$ufzj
000837426 773__ $$0PERI:(DE-600)2040222-3$$a10.2967/jnumed.117.196709$$gp. jnumed.117.196709 -$$n4$$p603-609$$tJournal of nuclear medicine$$v59$$x2159-662X$$y2018
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