TY  - JOUR
AU  - Mauler, Jörg
AU  - Maudsley, Andrew A.
AU  - Langen, Karl-Josef
AU  - Nikoubashman, Omid
AU  - Stoffels, Gabriele
AU  - Sheriff, Sulaiman
AU  - Lohmann, Philipp
AU  - Filss, Christian
AU  - Galldiks, Norbert
AU  - Rota Kops, Elena
AU  - Shah, N. J.
TI  - Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study
JO  - Journal of nuclear medicine
VL  - 59
IS  - 4
SN  - 2159-662X
CY  - New York, NY
PB  - Soc.
M1  - FZJ-2017-06351
SP  - 603-609
PY  - 2018
AB  - PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and may represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed.
LB  - PUB:(DE-HGF)16
C6  - pmid:28848036
UR  - <Go to ISI:>//WOS:000428981100021
DO  - DOI:10.2967/jnumed.117.196709
UR  - https://juser.fz-juelich.de/record/837426
ER  -