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@ARTICLE{Mauler:837426,
      author       = {Mauler, Jörg and Maudsley, Andrew A. and Langen,
                      Karl-Josef and Nikoubashman, Omid and Stoffels, Gabriele and
                      Sheriff, Sulaiman and Lohmann, Philipp and Filss, Christian
                      and Galldiks, Norbert and Rota Kops, Elena and Shah, N. J.},
      title        = {{S}patial {R}elationship of {G}lioma {V}olume {D}erived
                      from {FET} {PET} and {V}olumetric {MRSI}: a hybrid
                      {PET}-{MRI} study},
      journal      = {Journal of nuclear medicine},
      volume       = {59},
      number       = {4},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {FZJ-2017-06351},
      pages        = {603-609},
      year         = {2018},
      abstract     = {PET imaging of amino acid transport using
                      O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR
                      spectroscopy (MRS) imaging of cell turnover measured by the
                      ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide
                      additional information on tumor extent of cerebral gliomas
                      compared with anatomic imaging; however, comparative studies
                      are rare. Methods: In this prospective study, 41 patients
                      (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral
                      gliomas (World Health Organization [WHO] grade II: 10
                      [including 1 patient with 2 lesions], WHO III: 17, WHO IV:
                      13, without biopsy low-grade: 1, high-grade: 1) were
                      investigated with a hybrid PET/MR scanner. Tumor extent,
                      spatial overlap, and the distance between the corresponding
                      centers of mass in 18F-FET PET and MRS imaging of Cho/NAA,
                      determined by simultaneously acquired, 3-dimensional
                      spatially resolved MRS imaging data, were compared. Results:
                      The average tumor volumes for 18F-FET uptake and increased
                      Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3,
                      respectively, with an overlap of $40\%$ ± $25\%$ and
                      separation of the centers of mass by 9 ± 8 mm. None of the
                      parameters showed a significant correlation with tumor
                      grade. Conclusion: 18F-FET uptake and increased Cho/NAA
                      ratio are not always congruent and may represent different
                      properties of glioma metabolism. The relationship to
                      histologic tumor extent needs to be further analyzed.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28848036},
      UT           = {WOS:000428981100021},
      doi          = {10.2967/jnumed.117.196709},
      url          = {https://juser.fz-juelich.de/record/837426},
}