TY  - JOUR
AU  - Buchholz, Martin
AU  - Spahn, Ingo
AU  - Coenen, Heinrich Hubert
TI  - Optimized separation procedure for production of no-carrier-added radiomanganese for positron emission tomography
JO  - Radiochimica acta
VL  - 103
IS  - 12
SN  - 2193-3405
CY  - Berlin
PB  - De Gruyter
M1  - FZJ-2017-06369
SP  - 7
PY  - 2015
AB  - The natCr(p, xn)-process is a very efficient route for production of 52gMn (T1/2 = 5.59 d). Based on measurements of distribution coefficients with different media and ion-exchange resins, an optimized chromatographic separation of radiomanganese from natCr with the resin Amberlite CG400 was developed. With this system natCr is eluted first with an acetic acid/methanol 1:1 mixture at room temperature and 52gMn thereafter with 3 M HCl at 50 ℃. Within a separation time of 4 h the method yielded 99.5% of the n.c.a. 52gMn in 2–3 mL of 3 M HCl. An ICP-MS analysis revealed a chromium impurity of 0.07 mg (0.014%) in the n.c.a. 52gMn solution, making this separation method suitable for the production of 52gMn for medical applications like positron emission tomography (PET).
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000366187300008
DO  - DOI:10.1515/ract-2015-2506
UR  - https://juser.fz-juelich.de/record/837456
ER  -