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@ARTICLE{Radke:837514,
      author       = {Radke, Sina and Hoffstaedter, Felix and Löffler, Leonie
                      and Kogler, Lydia and Schneider, Frank and Blechert, Jens
                      and Derntl, Birgit},
      title        = {{I}maging the up’s and down’s of emotion regulation in
                      lifetime depression},
      journal      = {Brain imaging and behavior},
      volume       = {12},
      number       = {1},
      issn         = {1931-7565},
      address      = {New York, NY [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2017-06410},
      pages        = {156–167},
      year         = {2018},
      abstract     = {Reappraisal is a particularly effective strategy for
                      influencing emotional experiences, specifically for reducing
                      the impact of negative stimuli. Although depression has
                      repeatedly been linked to dysfunctional behavioral and
                      neural emotion regulation, prefrontal and amygdala
                      engagement seems to vary with clinical characteristics and
                      the specific regulation strategy used. Whereas previous
                      neuroimaging research has focused on down-regulating
                      reactions to emotionally evocative scenes, the current study
                      compared up- and down-regulation in response to angry facial
                      expressions in patients with depression and healthy
                      individuals. During the initial viewing of faces, patients
                      with depression showed hypoactivation particularly in areas
                      implicated in emotion generation, i.e., amygdala, insula and
                      putamen. In contrast, up-regulating negative emotions
                      yielded stronger recruitment of core face processing areas
                      and posterior medial frontal cortex in patients than in
                      controls. However, group differences did not extend to
                      resting-state functional connectivity. Recurrent depression
                      was inversely associated with amygdala activation
                      specifically during down-regulation, but differences in
                      medication status may limit the current findings. Despite a
                      pattern of reduced neural emotional reactivity in mainly
                      medicated patients, their ‘successful’ recruitment of
                      the regulation network for up-regulation might point toward
                      an effective use of reappraisal when increasing negative
                      emotions. Future studies need to address how patients might
                      benefit from transferring this ability to adaptive goals,
                      such as improving interpersonal emotion regulation.},
      cin          = {INM-1 / INM-7 / INM-10},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406 /
                      I:(DE-Juel1)INM-10-20170113},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28197859},
      UT           = {WOS:000425307500014},
      doi          = {10.1007/s11682-017-9682-2},
      url          = {https://juser.fz-juelich.de/record/837514},
}