TY  - JOUR
AU  - Bilatto, Stanley E. R.
AU  - Adly, Nouran
AU  - Correa, Daniel S.
AU  - Wolfrum, Bernhard
AU  - Offenhäusser, Andreas
AU  - Yakushenko, Alexey
TI  - Printed microfluidic filter for heparinized blood
JO  - Biomicrofluidics
VL  - 11
IS  - 3
SN  - 1932-1058
CY  - Melville, NY
PB  - AIP
M1  - FZJ-2017-06411
SP  - 034101 -
PY  - 2017
AB  - A simple lab-on-a-chip method for blood plasma separation was developed by combining stereolithographic 3D printing with inkjet printing, creating a completely sealed microfluidic device. In some approaches, one dilutes the blood sample before separation, reducing the concentration of a target analyte and increasing a contamination risk. In this work, a single drop (8 μl) of heparinized whole blood could be efficiently filtered using a capillary effect without any external driving forces and without dilution. The blood storage in heparin tubes during 24 h at 4 °C initiated the formation of small crystals that formed auto-filtration structures in the sample upon entering the 3D-printed device, with pores smaller than the red blood cells, separating plasma from the cellular content. The total filtration process took less than 10 s. The presented printed plasma filtration microfluidics fabricated with a rapid prototyping approach is a miniaturized, fast and easy-to-operate device that can be integrated into healthcare/portable systems for point-of-care diagnostics.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000404340600003
C6  - pmid:28798855
DO  - DOI:10.1063/1.4982963
UR  - https://juser.fz-juelich.de/record/837515
ER  -