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@ARTICLE{Bilatto:837515,
      author       = {Bilatto, Stanley E. R. and Adly, Nouran and Correa, Daniel
                      S. and Wolfrum, Bernhard and Offenhäusser, Andreas and
                      Yakushenko, Alexey},
      title        = {{P}rinted microfluidic filter for heparinized blood},
      journal      = {Biomicrofluidics},
      volume       = {11},
      number       = {3},
      issn         = {1932-1058},
      address      = {Melville, NY},
      publisher    = {AIP},
      reportid     = {FZJ-2017-06411},
      pages        = {034101 -},
      year         = {2017},
      abstract     = {A simple lab-on-a-chip method for blood plasma separation
                      was developed by combining stereolithographic 3D printing
                      with inkjet printing, creating a completely sealed
                      microfluidic device. In some approaches, one dilutes the
                      blood sample before separation, reducing the concentration
                      of a target analyte and increasing a contamination risk. In
                      this work, a single drop (8 μl) of heparinized whole
                      blood could be efficiently filtered using a capillary effect
                      without any external driving forces and without dilution.
                      The blood storage in heparin tubes during 24 h at 4 °C
                      initiated the formation of small crystals that formed
                      auto-filtration structures in the sample upon entering the
                      3D-printed device, with pores smaller than the red blood
                      cells, separating plasma from the cellular content. The
                      total filtration process took less than 10 s. The
                      presented printed plasma filtration microfluidics fabricated
                      with a rapid prototyping approach is a miniaturized, fast
                      and easy-to-operate device that can be integrated into
                      healthcare/portable systems for point-of-care diagnostics.},
      cin          = {ICS-8},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000404340600003},
      pubmed       = {pmid:28798855},
      doi          = {10.1063/1.4982963},
      url          = {https://juser.fz-juelich.de/record/837515},
}