Disinhibition and inhibition of HCN2 channel function by ligand binding to the cyclic nucleotide bin

CoordinatorGohlke, Holger
Grant period2017-05-01 - 2018-04-30
Funding bodyNIC
IdentifierG:(DE-Juel1)hdd17_20170501

Energetic and structural characterization of the activation processes of the human HCN2 ion channel

Note: JSC computation time grant
 

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N 6 -modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels
The journal of biological chemistry 294, 17978-17987 () [10.1074/jbc.RA119.010246] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Isoform-specific Inhibition of N-methyl-D-aspartate Receptors by Bile Salts
Scientific reports 9(1), 10068 () [10.1038/s41598-019-46496-y] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation
Scientific reports 8(1), 14960 () [10.1038/s41598-018-33050-5] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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 Record created 2017-09-14, last modified 2020-09-21



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