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@ARTICLE{Toulmin:837797,
      author       = {Toulmin, A. and Baltierra-Jasso, L. E. and Morten, M. J.
                      and Sabir, T. and McGlynn, P. and Schröder, Gunnar and
                      Smith, B. O. and Magennis, S. W.},
      title        = {{C}onformational {H}eterogeneity in a {F}ully
                      {C}omplementary {DNA} {T}hree-{W}ay {J}unction with a
                      {GC}-{R}ich {B}ranchpoint.},
      journal      = {Biochemistry},
      volume       = {56},
      number       = {37},
      issn         = {0006-2960},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2017-06586},
      pages        = {4985–4991},
      year         = {2017},
      abstract     = {DNA three-way junctions (3WJs) are branched structures that
                      serve as important biological intermediates and as
                      components in DNA nanostructures. We recently derived the
                      global structure of a fully complementary 3WJ and found that
                      it contained unpaired bases at the branchpoint, which is
                      consistent with previous observations of branch flexibility
                      and branchpoint reactivity. By combining high-resolution
                      single-molecule Förster resonance energy transfer,
                      molecular modeling, time-resolved ensemble fluorescence
                      spectroscopy, and the first 19F nuclear magnetic resonance
                      observations of fully complementary 3WJs, we now show that
                      the 3WJ structure can adopt multiple distinct conformations
                      depending upon the sequence at the branchpoint. A 3WJ with a
                      GC-rich branchpoint adopts an open conformation with
                      unpaired bases at the branch and at least one additional
                      conformation with an increased number of base interactions
                      at the branchpoint. This structural diversity has
                      implications for branch interactions and processing in vivo
                      and for technological applications.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28820590},
      UT           = {WOS:000411548900009},
      doi          = {10.1021/acs.biochem.7b00677},
      url          = {https://juser.fz-juelich.de/record/837797},
}