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@ARTICLE{Ravichandran:837824,
      author       = {Ravichandran, Arvind and Saggiorato, Guglielmo and Auth,
                      Thorsten and Gompper, Gerhard and Vliegenthart, Gerrit},
      title        = {{E}nhanced {D}ynamics of {C}onfined {C}ytoskeletal
                      {F}ilaments {D}riven by {A}symmetric {M}otors},
      journal      = {Biophysical journal},
      volume       = {113},
      number       = {5},
      issn         = {0006-3495},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {FZJ-2017-06608},
      pages        = {1121 - 1132},
      year         = {2017},
      abstract     = {Cytoskeletal filaments and molecular motors facilitate the
                      micron-scale force generation necessary for the distribution
                      of organelles and the restructuring of the cytoskeleton
                      within eukaryotic cells. Although the mesoscopic structure
                      and the dynamics of such filaments have been studied in
                      vitro and in vivo, their connection with filament
                      polarity-dependent motor-mediated force generation is not
                      well understood. Using 2D Brownian dynamics simulations, we
                      study a dense, confined mixture of rigid microtubules (MTs)
                      and active springs that have arms that cross-link
                      neighboring MT pairs and move unidirectionally on the
                      attached MT. We simulate depletion interactions between MTs
                      using an attractive potential. We show that dimeric motors,
                      with a motile arm on only one of the two MTs, produce large
                      polarity-sorted MT clusters, whereas tetrameric motors, with
                      motile arms on both microtubules, produce bundles.
                      Furthermore, dimeric motors induce, on average, higher
                      velocities between antialigned MTs than tetrameric motors.
                      Our results, where MTs move faster near the confining wall,
                      are consistent with experimental observations in Drosophila
                      oocytes where enhanced microtubule activity is found close
                      to the confining plasma membrane.},
      cin          = {ICS-2 / IAS-2 / JARA-HPC},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / I:(DE-Juel1)IAS-2-20090406 /
                      $I:(DE-82)080012_20140620$},
      pnm          = {552 - Engineering Cell Function (POF3-552) / Hydrodynamics
                      of Active Biological Systems $(jiff26_20110501)$},
      pid          = {G:(DE-HGF)POF3-552 / $G:(DE-Juel1)jiff26_20110501$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000410462300015},
      pubmed       = {pmid:28877494},
      doi          = {10.1016/j.bpj.2017.07.016},
      url          = {https://juser.fz-juelich.de/record/837824},
}