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000837921 1001_ $$0P:(DE-HGF)0$$aSu, Shijie$$b0
000837921 245__ $$aComparative transcriptome analysis of second- and third-generation merozoites of Eimeria necatrix
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000837921 520__ $$aBackgroundEimeria is a common genus of apicomplexan parasites that infect diverse vertebrates, most notably poultry, causing serious disease and economic losses. Eimeria species have complex life-cycles consisting of three developmental stages. However, the molecular basis of the Eimeria reproductive mode switch remains an enigma.MethodsTotal RNA extracted from second- (MZ-2) and third-generation merozoites (MZ-3) of Eimeria necatrix was subjected to transcriptome analysis using RNA sequencing (RNA-seq) followed by qRT-PCR validation.ResultsA total of 6977 and 6901 unigenes were obtained from MZ-2 and MZ-3, respectively. Approximately 2053 genes were differentially expressed genes (DEGs) between MZ-2 and MZ-3. Compared with MZ-2, 837 genes were upregulated and 1216 genes were downregulated in MZ-3. Approximately 95 genes in MZ-2 and 48 genes in MZ-3 were further identified to have stage-specific expression. Gene ontology category and KEGG analysis suggested that 216 upregulated genes in MZ-2 were annotated by 70 GO assignments, 242 upregulated genes were associated with 188 signal pathways, while 321 upregulated genes in MZ-3 were annotated by 56 GO assignments, 322 upregulated genes were associated with 168 signal pathways. The molecular functions of upregulated genes in MZ-2 were mainly enriched for protein degradation and amino acid metabolism. The molecular functions of upregulated genes in MZ-3 were mainly enriched for transcriptional activity, cell proliferation and cell differentiation.
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000837921 7001_ $$0P:(DE-HGF)0$$aHou, Zhaofeng$$b1
000837921 7001_ $$0P:(DE-HGF)0$$aLiu, Dandan$$b2
000837921 7001_ $$0P:(DE-Juel1)130736$$aJia, Chun-Lin$$b3
000837921 7001_ $$0P:(DE-HGF)0$$aWang, Lele$$b4
000837921 7001_ $$0P:(DE-HGF)0$$aXu, Jinjun$$b5
000837921 7001_ $$0P:(DE-HGF)0$$aTao, Jianping$$b6$$eCorresponding author
000837921 773__ $$0PERI:(DE-600)2409480-8$$a10.1186/s13071-017-2325-z$$gVol. 10, no. 1, p. 388$$n1$$p388$$tParasites & vectors$$v10$$x1756-3305$$y2017
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