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@ARTICLE{Su:837921,
      author       = {Su, Shijie and Hou, Zhaofeng and Liu, Dandan and Jia,
                      Chun-Lin and Wang, Lele and Xu, Jinjun and Tao, Jianping},
      title        = {{C}omparative transcriptome analysis of second- and
                      third-generation merozoites of {E}imeria necatrix},
      journal      = {Parasites $\&$ vectors},
      volume       = {10},
      number       = {1},
      issn         = {1756-3305},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2017-06691},
      pages        = {388},
      year         = {2017},
      abstract     = {BackgroundEimeria is a common genus of apicomplexan
                      parasites that infect diverse vertebrates, most notably
                      poultry, causing serious disease and economic losses.
                      Eimeria species have complex life-cycles consisting of three
                      developmental stages. However, the molecular basis of the
                      Eimeria reproductive mode switch remains an
                      enigma.MethodsTotal RNA extracted from second- (MZ-2) and
                      third-generation merozoites (MZ-3) of Eimeria necatrix was
                      subjected to transcriptome analysis using RNA sequencing
                      (RNA-seq) followed by qRT-PCR validation.ResultsA total of
                      6977 and 6901 unigenes were obtained from MZ-2 and MZ-3,
                      respectively. Approximately 2053 genes were differentially
                      expressed genes (DEGs) between MZ-2 and MZ-3. Compared with
                      MZ-2, 837 genes were upregulated and 1216 genes were
                      downregulated in MZ-3. Approximately 95 genes in MZ-2 and 48
                      genes in MZ-3 were further identified to have stage-specific
                      expression. Gene ontology category and KEGG analysis
                      suggested that 216 upregulated genes in MZ-2 were annotated
                      by 70 GO assignments, 242 upregulated genes were associated
                      with 188 signal pathways, while 321 upregulated genes in
                      MZ-3 were annotated by 56 GO assignments, 322 upregulated
                      genes were associated with 168 signal pathways. The
                      molecular functions of upregulated genes in MZ-2 were mainly
                      enriched for protein degradation and amino acid metabolism.
                      The molecular functions of upregulated genes in MZ-3 were
                      mainly enriched for transcriptional activity, cell
                      proliferation and cell differentiation.},
      cin          = {ER-C-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-1-20170209},
      pnm          = {143 - Controlling Configuration-Based Phenomena (POF3-143)},
      pid          = {G:(DE-HGF)POF3-143},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000408039700002},
      pubmed       = {pmid:28814335},
      doi          = {10.1186/s13071-017-2325-z},
      url          = {https://juser.fz-juelich.de/record/837921},
}