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| Hauptseite > Publikationsdatenbank > Comparative transcriptome analysis of second- and third-generation merozoites of Eimeria necatrix > print |
| Hauptseite > Publikationsdatenbank > Comparative transcriptome analysis of second- and third-generation merozoites of Eimeria necatrix > print |
| 001 | 837921 | ||
| 005 | 20210129231445.0 | ||
| 024 | 7 | _ | |a 10.1186/s13071-017-2325-z |2 doi |
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| 100 | 1 | _ | |a Su, Shijie |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Comparative transcriptome analysis of second- and third-generation merozoites of Eimeria necatrix |
| 260 | _ | _ | |a London |c 2017 |b BioMed Central |
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| 520 | _ | _ | |a BackgroundEimeria is a common genus of apicomplexan parasites that infect diverse vertebrates, most notably poultry, causing serious disease and economic losses. Eimeria species have complex life-cycles consisting of three developmental stages. However, the molecular basis of the Eimeria reproductive mode switch remains an enigma.MethodsTotal RNA extracted from second- (MZ-2) and third-generation merozoites (MZ-3) of Eimeria necatrix was subjected to transcriptome analysis using RNA sequencing (RNA-seq) followed by qRT-PCR validation.ResultsA total of 6977 and 6901 unigenes were obtained from MZ-2 and MZ-3, respectively. Approximately 2053 genes were differentially expressed genes (DEGs) between MZ-2 and MZ-3. Compared with MZ-2, 837 genes were upregulated and 1216 genes were downregulated in MZ-3. Approximately 95 genes in MZ-2 and 48 genes in MZ-3 were further identified to have stage-specific expression. Gene ontology category and KEGG analysis suggested that 216 upregulated genes in MZ-2 were annotated by 70 GO assignments, 242 upregulated genes were associated with 188 signal pathways, while 321 upregulated genes in MZ-3 were annotated by 56 GO assignments, 322 upregulated genes were associated with 168 signal pathways. The molecular functions of upregulated genes in MZ-2 were mainly enriched for protein degradation and amino acid metabolism. The molecular functions of upregulated genes in MZ-3 were mainly enriched for transcriptional activity, cell proliferation and cell differentiation. |
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| 700 | 1 | _ | |a Hou, Zhaofeng |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Liu, Dandan |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a Wang, Lele |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Xu, Jinjun |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Tao, Jianping |0 P:(DE-HGF)0 |b 6 |e Corresponding author |
| 773 | _ | _ | |a 10.1186/s13071-017-2325-z |g Vol. 10, no. 1, p. 388 |0 PERI:(DE-600)2409480-8 |n 1 |p 388 |t Parasites & vectors |v 10 |y 2017 |x 1756-3305 |
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