TY  - JOUR
AU  - Jin, Lei
AU  - Jin, Lei
AU  - Yu, Jingru
AU  - Xu, Yanjun
AU  - Liu, Hui
AU  - Ren, Aiguo
TI  - Prevalence of Neural Tube Defects and the Impact of Prenatal Diagnosis in Three Districts of Beijing, China
JO  - Paediatric and perinatal epidemiology
VL  - 31
IS  - 4
SN  - 0269-5022
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - FZJ-2017-06704
SP  - 293 - 300
PY  - 2017
AB  - BackgroundThe objectives of this study were to explore the prevalence of neural tube defects (NTDs) in three districts of Beijing, and to evaluate the impact of prenatal diagnosis on the prevalence.MethodsData were collected between 2006 and 2012 from the Beijing Birth Defects Surveillance System. P13 and P28 represent the prevalence of NTDs diagnosed from 13 weeks and 28 weeks of gestation, respectively, to 7 days after delivery. Populations were classified as household (permanent) and non-household (non-permanent) because differences exist in access to health care, education, and income, among others.ResultsThe P13 of NTDs was 11.7 per 10 000 births in the three districts, which declined from 2006–12. In addition, the prevalence of NTDs in the non-household population was 1.7-fold higher than that among the household population. The P13 of anencephaly, spina bifida, and encephalocele were 5.3, 4.9, 1.6, respectively, per 10 000 births. The P28 of NTDs only represented 29.1% of P13, and this proportion decreased over the 7-year period.ConclusionsThe prevalence of NTDs remains high in the three districts of Beijing, and the rate was higher in the non-household than household population. The prevalence of birth defects would be under estimated by almost 70 per cent if the report time was set on 28 weeks’ gestation or later compared with report time on 13 weeks of gestation. It is better to set the report time earlier in birth defect surveillance in contemporary China.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000405827300007
DO  - DOI:10.1111/ppe.12354
UR  - https://juser.fz-juelich.de/record/837943
ER  -