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| Hauptseite > Publikationsdatenbank > Geno- and Cytotoxicity of DNA-associated Auger Electron emitters > print |
| Hauptseite > Publikationsdatenbank > Geno- and Cytotoxicity of DNA-associated Auger Electron emitters > print |
| 001 | 837946 | ||
| 005 | 20210129231449.0 | ||
| 024 | 7 | _ | |a 2128/15672 |2 Handle |
| 037 | _ | _ | |a FZJ-2017-06707 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Kriehuber, Ralf |0 P:(DE-Juel1)133469 |b 0 |e Corresponding author |
| 111 | 2 | _ | |a Joint Meeting of the European Radiation Research Society and the Society for Biological Radiation Research |g ERRS and GBS |c Essen |d 2017-09-17 - 2017-09-21 |w Germany |
| 245 | _ | _ | |a Geno- and Cytotoxicity of DNA-associated Auger Electron emitters |
| 260 | _ | _ | |c 2017 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
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| 520 | _ | _ | |a Theoretical considerations, Monte-Carlo simulations and experimental findings suggest that DNA-incorporated Auger electron emitters (AEE) cause primarily complex and clustered DNA lesions. It was previously shown that the shape of AEE-induced cell survival curves resembles that of High-LET irradiation and, therefore, poses the question of an increased biological effectiveness and a separate quality factor for Auger electrons. During electron capture or internal conversion an electron vacancy in an inner atomic shell is created. Filling the electron vacancy by a higher shell electron can initiate a process of non-radiative energy transmission, commonly termed as “Auger effect”. During the process numerous low-energy Auger electrons (up to 27 in the case of Iodine-125) with a short range are emitted leading to energy densities and free radical production in the close vicinity of the emitter exceeding that of a 5 MeV alpha-particle traversing the DNA double-helix. Experimental data demonstrate, that the cyto- and genotoxicity of AEE is comparable to low-LET radiation per unit dose when the AEE is exclusively located in the cytoplasm. However, in case of DNA-incorporation RBEs ranging from 5 – 9 are frequently reported. Employing the alkaline and neutral comet assay, the high DSB/SSB ratio of I-125-iododeoxyuridine derived from Monte-Carlo simulations could be experimentally confirmed. The unique properties of AEE and the possibility to target DNA in a sequence-specific manner using AEE-labeled Triplex-forming oligonucleotides (TFOs) enable to study the repair of complex DNA lesions at defined sites in more detail. A transgenic SCL-II p2RT strain carrying the stably integrated recoverable p2RT vector system harboring a specific triplex target sequence for TFO-p2RT will help to analyze the repair efficiency of complex DNA lesions regarding mutation frequency, mutation type and mutation localization. |
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| 700 | 1 | _ | |a Pomplun, Ekkehard |0 P:(DE-Juel1)133341 |b 4 |
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