000838055 001__ 838055
000838055 005__ 20220930130132.0
000838055 0247_ $$2doi$$a10.3389/fnana.2017.00078
000838055 0247_ $$2Handle$$a2128/15381
000838055 0247_ $$2WOS$$aWOS:000411238900001
000838055 0247_ $$2altmetric$$aaltmetric:26344180
000838055 0247_ $$2pmid$$apmid:28970785
000838055 037__ $$aFZJ-2017-06794
000838055 041__ $$aEnglish
000838055 082__ $$a610
000838055 1001_ $$0P:(DE-Juel1)131714$$aZilles, Karl$$b0$$eCorresponding author$$ufzj
000838055 245__ $$aMultiple Transmitter Receptors in Regions and Layers of the Human Cerebral Cortex
000838055 260__ $$aLausanne$$bFrontiers Research Foundation$$c2017
000838055 3367_ $$2DRIVER$$aarticle
000838055 3367_ $$2DataCite$$aOutput Types/Journal article
000838055 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1506600576_25937
000838055 3367_ $$2BibTeX$$aARTICLE
000838055 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000838055 3367_ $$00$$2EndNote$$aJournal Article
000838055 520__ $$aWe measured the densities (fmol/mg protein) of 15 different receptors of various transmitter systems in the supragranular, granular and infragranular strata of 44 areas of visual, somatosensory, auditory and multimodal association systems of the human cerebral cortex. Receptor densities were obtained after labeling of the receptors using quantitative in vitro receptor autoradiography in human postmortem brains. The mean density of each receptor type over all cortical layers and of each of the three major strata varies between cortical regions. In a single cortical area, the multi-receptor fingerprints of its strata (i.e., polar plots, each visualizing the densities of multiple different receptor types in supragranular, granular or infragranular layers of the same cortical area) differ in shape and size indicating regional and laminar specific balances between the receptors. Furthermore, the three strata are clearly segregated into well definable clusters by their receptor fingerprints. Fingerprints of different cortical areas systematically vary between functional networks, and with the hierarchical levels within sensory systems. Primary sensory areas are clearly separated from all other cortical areas particularly by their very high muscarinic M2 and nicotinic α4β2 receptor densities, and to a lesser degree also by noradrenergic α2 and serotonergic 5-HT2 receptors. Early visual areas of the dorsal and ventral streams are segregated by their multi-receptor fingerprints. The results are discussed on the background of functional segregation, cortical hierarchies, microstructural types, and the horizontal (layers) and vertical (columns) organization in the cerebral cortex. We conclude that a cortical column is composed of segments, which can be assigned to the cortical strata. The segments differ by their patterns of multi-receptor balances, indicating different layer-specific signal processing mechanisms. Additionally, the differences between the strata-and area-specific fingerprints of the 44 areas reflect the segregation of the cerebral cortex into functionally and topographically definable groups of cortical areas (visual, auditory, somatosensory, limbic, motor), and reveals their hierarchical position (primary and unimodal (early) sensory to higher sensory and finally to multimodal association areas).
000838055 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000838055 536__ $$0G:(EU-Grant)720270$$aHBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270)$$c720270$$fH2020-Adhoc-2014-20$$x1
000838055 588__ $$aDataset connected to CrossRef
000838055 7001_ $$0P:(DE-Juel1)131701$$aPalomero-Gallagher, Nicola$$b1$$ufzj
000838055 773__ $$0PERI:(DE-600)2452969-2$$a10.3389/fnana.2017.00078$$gVol. 11, p. 78$$p78$$tFrontiers in neuroanatomy$$v11$$x1662-5129$$y2017
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.pdf$$yOpenAccess
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.gif?subformat=icon$$xicon$$yOpenAccess
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000838055 8564_ $$uhttps://juser.fz-juelich.de/record/838055/files/fnana-11-00078.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000838055 8767_ $$92017-09-18$$d2017-09-18$$eAPC$$jDeposit$$lDeposit: Frontiers$$zUSD 1904,85
000838055 909CO $$ooai:juser.fz-juelich.de:838055$$popenCost$$pec_fundedresources$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000838055 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131714$$aForschungszentrum Jülich$$b0$$kFZJ
000838055 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131701$$aForschungszentrum Jülich$$b1$$kFZJ
000838055 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000838055 9141_ $$y2017
000838055 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000838055 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000838055 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000838055 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT NEUROANAT : 2015
000838055 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000838055 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000838055 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000838055 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000838055 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000838055 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000838055 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000838055 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000838055 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000838055 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
000838055 980__ $$ajournal
000838055 980__ $$aVDB
000838055 980__ $$aUNRESTRICTED
000838055 980__ $$aI:(DE-Juel1)INM-1-20090406
000838055 980__ $$aAPC
000838055 9801_ $$aAPC
000838055 9801_ $$aFullTexts