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@ARTICLE{Hammes:838378,
author = {Hammes, Jochen and Leuwer, Isabel and Bischof, Gérard N.
and Drzezga, Alexander and van Eimeren, Thilo},
title = {{M}ultimodal correlation of dynamic [18{F}]-{AV}-1451
perfusion {PET} and neuronal hypometabolism in [18{F}]-{FDG}
{PET}.},
journal = {European journal of nuclear medicine and molecular imaging},
volume = {44},
number = {13},
issn = {1619-7089},
address = {Heidelberg [u.a.]},
publisher = {Springer-Verl.},
reportid = {FZJ-2017-06990},
pages = {2249–2256},
year = {2017},
abstract = {PurposeCerebral glucose metabolism measured with [18F]-FDG
PET is a well established marker of neuronal dysfunction in
neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET
is currently under evaluation and shows promising results.
Here, we assess the feasibility of early perfusion imaging
with AV-1451 as a substite for FDG PET in assessing neuronal
injury.MethodsTwenty patients with suspected
neurodegeneration underwent FDG and early phase AV-1451 PET
imaging. Ten one-minute timeframes were acquired after
application of 200 MBq AV-1451. FDG images were acquired on
a different date according to clinical protocol. Early
AV-1451 timeframes were coregistered to individual FDG-scans
and spatially normalized. Voxel-wise intermodal correlations
were calculated on within-subject level for every possible
time window. The window with highest pooled correlation was
considered optimal. Z-transformed deviation maps (ZMs) were
created from both FDG and early AV-1451 images, comparing
against FDG images of healthy controls.ResultsRegional
patterns and extent of perfusion deficits were highly
comparable to metabolic deficits. Best results were observed
in a time window from 60 to 360 s (r = 0.86). Correlation
strength ranged from r = 0.96 (subcortical gray matter) to
0.83 (frontal lobe) in regional analysis. ZMs of early
AV-1451 and FDG images were highly
similar.ConclusionPerfusion imaging with AV-1451 is a valid
biomarker for assessment of neuronal dysfunction in
neurodegenerative diseases. Radiation exposure and
complexity of the diagnostic workup could be reduced
significantly by routine acquisition of early AV-1451
images, sparing additional FDG PET.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29026951},
UT = {WOS:000415085500012},
doi = {10.1007/s00259-017-3840-z},
url = {https://juser.fz-juelich.de/record/838378},
}