% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hammes:838378,
      author       = {Hammes, Jochen and Leuwer, Isabel and Bischof, Gérard N.
                      and Drzezga, Alexander and van Eimeren, Thilo},
      title        = {{M}ultimodal correlation of dynamic [18{F}]-{AV}-1451
                      perfusion {PET} and neuronal hypometabolism in [18{F}]-{FDG}
                      {PET}.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {44},
      number       = {13},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2017-06990},
      pages        = {2249–2256},
      year         = {2017},
      abstract     = {PurposeCerebral glucose metabolism measured with [18F]-FDG
                      PET is a well established marker of neuronal dysfunction in
                      neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET
                      is currently under evaluation and shows promising results.
                      Here, we assess the feasibility of early perfusion imaging
                      with AV-1451 as a substite for FDG PET in assessing neuronal
                      injury.MethodsTwenty patients with suspected
                      neurodegeneration underwent FDG and early phase AV-1451 PET
                      imaging. Ten one-minute timeframes were acquired after
                      application of 200 MBq AV-1451. FDG images were acquired on
                      a different date according to clinical protocol. Early
                      AV-1451 timeframes were coregistered to individual FDG-scans
                      and spatially normalized. Voxel-wise intermodal correlations
                      were calculated on within-subject level for every possible
                      time window. The window with highest pooled correlation was
                      considered optimal. Z-transformed deviation maps (ZMs) were
                      created from both FDG and early AV-1451 images, comparing
                      against FDG images of healthy controls.ResultsRegional
                      patterns and extent of perfusion deficits were highly
                      comparable to metabolic deficits. Best results were observed
                      in a time window from 60 to 360 s (r = 0.86). Correlation
                      strength ranged from r = 0.96 (subcortical gray matter) to
                      0.83 (frontal lobe) in regional analysis. ZMs of early
                      AV-1451 and FDG images were highly
                      similar.ConclusionPerfusion imaging with AV-1451 is a valid
                      biomarker for assessment of neuronal dysfunction in
                      neurodegenerative diseases. Radiation exposure and
                      complexity of the diagnostic workup could be reduced
                      significantly by routine acquisition of early AV-1451
                      images, sparing additional FDG PET.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29026951},
      UT           = {WOS:000415085500012},
      doi          = {10.1007/s00259-017-3840-z},
      url          = {https://juser.fz-juelich.de/record/838378},
}