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| Hauptseite > Publikationsdatenbank > Multimodal correlation of dynamic [18F]-AV-1451 perfusion PET and neuronal hypometabolism in [18F]-FDG PET. > print |
| Hauptseite > Publikationsdatenbank > Multimodal correlation of dynamic [18F]-AV-1451 perfusion PET and neuronal hypometabolism in [18F]-FDG PET. > print |
| 001 | 838378 | ||
| 005 | 20210129231535.0 | ||
| 024 | 7 | _ | |a 10.1007/s00259-017-3840-z |2 doi |
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| 024 | 7 | _ | |a 1619-7070 |2 ISSN |
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| 100 | 1 | _ | |a Hammes, Jochen |0 0000-0003-2850-9450 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Multimodal correlation of dynamic [18F]-AV-1451 perfusion PET and neuronal hypometabolism in [18F]-FDG PET. |
| 260 | _ | _ | |a Heidelberg [u.a.] |c 2017 |b Springer-Verl. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a PurposeCerebral glucose metabolism measured with [18F]-FDG PET is a well established marker of neuronal dysfunction in neurodegeneration. The tau-protein tracer [18F]-AV-1451 PET is currently under evaluation and shows promising results. Here, we assess the feasibility of early perfusion imaging with AV-1451 as a substite for FDG PET in assessing neuronal injury.MethodsTwenty patients with suspected neurodegeneration underwent FDG and early phase AV-1451 PET imaging. Ten one-minute timeframes were acquired after application of 200 MBq AV-1451. FDG images were acquired on a different date according to clinical protocol. Early AV-1451 timeframes were coregistered to individual FDG-scans and spatially normalized. Voxel-wise intermodal correlations were calculated on within-subject level for every possible time window. The window with highest pooled correlation was considered optimal. Z-transformed deviation maps (ZMs) were created from both FDG and early AV-1451 images, comparing against FDG images of healthy controls.ResultsRegional patterns and extent of perfusion deficits were highly comparable to metabolic deficits. Best results were observed in a time window from 60 to 360 s (r = 0.86). Correlation strength ranged from r = 0.96 (subcortical gray matter) to 0.83 (frontal lobe) in regional analysis. ZMs of early AV-1451 and FDG images were highly similar.ConclusionPerfusion imaging with AV-1451 is a valid biomarker for assessment of neuronal dysfunction in neurodegenerative diseases. Radiation exposure and complexity of the diagnostic workup could be reduced significantly by routine acquisition of early AV-1451 images, sparing additional FDG PET. |
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