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@ARTICLE{Tarenzi:838466,
author = {Tarenzi, Thomas and Calandrini, Vania and Potestio,
Raffaello and Giorgetti, Alejandro and Carloni, Paolo},
title = {{O}pen {B}oundary {S}imulations of {P}roteins and {T}heir
{H}ydration {S}hells by {H}amiltonian {A}daptive
{R}esolution {S}cheme},
journal = {Journal of chemical theory and computation},
volume = {13},
number = {11},
issn = {1549-9626},
address = {Washington, DC},
reportid = {FZJ-2017-07069},
pages = {5647–5657},
year = {2017},
abstract = {The recently proposed Hamiltonian Adaptive Resolution
Scheme (H-AdResS) allows to perform molecular simulations in
an open boundary framework. It allows to change on the fly
the resolution of specific subset of molecules (usually the
solvent), which are free to diffuse between the atomistic
region and the coarse-grained reservoir. So far, the method
has been successfully applied to pure liquids. Coupling the
H-AdResS methodology to hybrid models of proteins, such as
the Molecular Mechanics/Coarse-Grained (MM/CG) scheme, is a
promising approach for rigorous calculations of ligand
binding free energies in low-resolution protein models.
Towards this goal, here we apply for the first time H-AdResS
to two atomistic proteins in dual-resolution solvent,
proving its ability to reproduce structural and dynamic
properties of both the proteins and the solvent, as obtained
from atomistic simulations.},
cin = {IAS-5 / INM-9},
ddc = {540},
cid = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
pnm = {574 - Theory, modelling and simulation (POF3-574)},
pid = {G:(DE-HGF)POF3-574},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28992702},
UT = {WOS:000415911800041},
doi = {10.1021/acs.jctc.7b00508},
url = {https://juser.fz-juelich.de/record/838466},
}