% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Verger:838516,
      author       = {Verger, Antoine and Stoffels, Gabriele and Bauer, Elena K.
                      and Lohmann, Philipp and Blau, Tobias and Fink, Gereon R.
                      and Neumaier, Bernd and Shah, Nadim J. and Langen,
                      Karl-Josef and Galldiks, Norbert},
      title        = {{S}tatic and dynamic 18{F}–{FET} {PET} for the
                      characterization of gliomas defined by {IDH} and 1p/19q
                      status},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {45},
      number       = {3},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2017-07108},
      pages        = {443–451},
      year         = {2018},
      abstract     = {PurposeThe molecular features isocitrate dehydrogenase
                      (IDH) mutation and 1p/19q co-deletion have gained major
                      importance for both glioma typing and prognosis and have,
                      therefore, been integrated in the World Health Organization
                      (WHO) classification in 2016. The aim of this study was to
                      characterize static and dynamic
                      O-(2-18F-fluoroethyl)-L-tyrosine (18F–FET) PET parameters
                      in gliomas with or without IDH mutation or 1p/19q
                      co-deletion.MethodsNinety patients with newly diagnosed and
                      untreated gliomas with a static and dynamic 18F–FET PET
                      scan prior to evaluation of tumor tissue according to the
                      2016 WHO classification were identified retrospectively.
                      Mean and maximum tumor-to-brain ratios (TBRmean/max), as
                      well as dynamic parameters (time-to-peak and slope) of
                      18F–FET uptake were calculated.ResultsSixteen $(18\%)$
                      oligodendrogliomas (IDH mutated, 1p/19q co-deleted), 27
                      $(30\%)$ astrocytomas (IDH mutated only), and 47 $(52\%)$
                      glioblastomas (IDH wild type only) were identified. TBRmean,
                      TBRmax, TTP and slope discriminated between IDH mutated
                      astrocytomas and IDH wild type glioblastomas (P < 0.01).
                      TBRmean showed the best diagnostic performance (cut-off
                      1.95; sensitivity, $89\%;$ specificity, $67\%;$ accuracy,
                      $81\%).$ None of the parameters discriminated between
                      oligodendrogliomas (IDH mutated, 1p/19q co-deleted) and
                      glioblastomas or astrocytomas. Furthermore, TBRmean, TBRmax,
                      TTP, and slope discriminated between gliomas with and
                      without IDH mutation (p < 0.01). The best diagnostic
                      performance was obtained for the combination of TTP with
                      TBRmax or slope (accuracy, $73\%).ConclusionData$ suggest
                      that static and dynamic 18F–FET PET parameters may allow
                      determining non-invasively the IDH mutation status. However,
                      IDH mutated and 1p/19q co-deleted oligodendrogliomas cannot
                      be differentiated from glioblastomas and astrocytomas by
                      18F–FET PET.},
      cin          = {INM-3 / INM-4 / INM-5 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29043400},
      UT           = {WOS:000423396800014},
      doi          = {10.1007/s00259-017-3846-6},
      url          = {https://juser.fz-juelich.de/record/838516},
}