%0 Journal Article
%A Fu, Wangyang
%A Feng, Lingyan
%A Panaitov, Gregory
%A Kireev, Dmitry
%A Mayer, Dirk
%A Offenhäusser, Andreas
%A Krause, Hans-Joachim
%T Biosensing near the neutrality point of graphene
%J Science advances
%V 3
%N 10
%@ 2375-2548
%C Washington, DC [u.a.]
%I Assoc.
%M FZJ-2017-07281
%P e1701247 -
%D 2017
%X Over the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noise, the fundamental reason limiting the sensor resolution. Conventionally, to reach the largest sensing response, graphene transistors are operated at the point of maximum transconductance, where 1/f noise is found to be unfavorably high and poses a major limitation in any attempt to further improve the device sensitivity. We show that operating a graphene transistor in an ambipolar mode near its neutrality point can markedly reduce the 1/f noise in graphene. Remarkably, our data reveal that this reduction in the electronic noise is achieved with uncompromised sensing response of the graphene chips and thus significantly improving the signal-to-noise ratio—compared to that of a conventionally operated graphene transistor for conductance measurement. As a proof-of-concept demonstration of the usage of the aforementioned new sensing scheme to a broader range of biochemical sensing applications, we selected an HIV-related DNA hybridization as the test bed and achieved detections at picomolar concentrations.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29075669
%U <Go to ISI:>//WOS:000417998700028
%R 10.1126/sciadv.1701247
%U https://juser.fz-juelich.de/record/838721