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000838721 1001_ $$00000-0002-1090-0411$$aFu, Wangyang$$b0$$eCorresponding author
000838721 245__ $$aBiosensing near the neutrality point of graphene
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000838721 520__ $$aOver the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noise, the fundamental reason limiting the sensor resolution. Conventionally, to reach the largest sensing response, graphene transistors are operated at the point of maximum transconductance, where 1/f noise is found to be unfavorably high and poses a major limitation in any attempt to further improve the device sensitivity. We show that operating a graphene transistor in an ambipolar mode near its neutrality point can markedly reduce the 1/f noise in graphene. Remarkably, our data reveal that this reduction in the electronic noise is achieved with uncompromised sensing response of the graphene chips and thus significantly improving the signal-to-noise ratio—compared to that of a conventionally operated graphene transistor for conductance measurement. As a proof-of-concept demonstration of the usage of the aforementioned new sensing scheme to a broader range of biochemical sensing applications, we selected an HIV-related DNA hybridization as the test bed and achieved detections at picomolar concentrations.
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000838721 7001_ $$00000-0001-9817-8680$$aFeng, Lingyan$$b1
000838721 7001_ $$0P:(DE-Juel1)128715$$aPanaitov, Gregory$$b2
000838721 7001_ $$0P:(DE-Juel1)159559$$aKireev, Dmitry$$b3
000838721 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b4
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