TY  - JOUR
AU  - Fu, Wangyang
AU  - Feng, Lingyan
AU  - Panaitov, Gregory
AU  - Kireev, Dmitry
AU  - Mayer, Dirk
AU  - Offenhäusser, Andreas
AU  - Krause, Hans-Joachim
TI  - Biosensing near the neutrality point of graphene
JO  - Science advances
VL  - 3
IS  - 10
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - FZJ-2017-07281
SP  - e1701247 -
PY  - 2017
AB  - Over the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noise, the fundamental reason limiting the sensor resolution. Conventionally, to reach the largest sensing response, graphene transistors are operated at the point of maximum transconductance, where 1/f noise is found to be unfavorably high and poses a major limitation in any attempt to further improve the device sensitivity. We show that operating a graphene transistor in an ambipolar mode near its neutrality point can markedly reduce the 1/f noise in graphene. Remarkably, our data reveal that this reduction in the electronic noise is achieved with uncompromised sensing response of the graphene chips and thus significantly improving the signal-to-noise ratio—compared to that of a conventionally operated graphene transistor for conductance measurement. As a proof-of-concept demonstration of the usage of the aforementioned new sensing scheme to a broader range of biochemical sensing applications, we selected an HIV-related DNA hybridization as the test bed and achieved detections at picomolar concentrations.
LB  - PUB:(DE-HGF)16
C6  - pmid:29075669
UR  - <Go to ISI:>//WOS:000417998700028
DO  - DOI:10.1126/sciadv.1701247
UR  - https://juser.fz-juelich.de/record/838721
ER  -