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@ARTICLE{Zobel:838756,
author = {Zobel, K. and Choi, Sung-Eun and Minakova, Rimma and
Gocyla, M. and Offenhäusser, A.},
title = {{N}-{C}adherin modified lipid bilayers promote neural
network formation and circuitry},
journal = {Soft matter},
volume = {13},
number = {44},
issn = {1744-6848},
address = {London},
publisher = {Royal Soc. of Chemistry},
reportid = {FZJ-2017-07293},
pages = {8096 - 8107},
year = {2017},
abstract = {Neural adhesion, maturation, and the correct wiring of the
brain to establish each neuron's intended connectivity are
controlled by complex interactions of bioactive molecules
such as ligands, growth factors, or enzymes. The correct
pairing of adjacent neurons is thought to be highly
regulated by ligand-mediated cell–cell adhesion proteins,
which are known to induce signaling activities. We developed
a new platform consisting of supported lipid bilayers
incorporated with Fc-chimera synaptic proteins like ephrinA5
or N-cadherin. We extensively characterized their function
employing a quartz crystal microbalance with dissipation
(QCM-D), calcium imaging, and immunofluorescence analysis.
Our biomimetic platform has been shown to promote neural
cell adhesion and to improve neural maturation at day in
vitro 7 (DIV7) as indicated by an elevated expression of
synaptophysin.},
cin = {ICS-8},
ddc = {530},
cid = {I:(DE-Juel1)ICS-8-20110106},
pnm = {552 - Engineering Cell Function (POF3-552)},
pid = {G:(DE-HGF)POF3-552},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29085948},
UT = {WOS:000415352100012},
doi = {10.1039/C7SM01214D},
url = {https://juser.fz-juelich.de/record/838756},
}