%0 Journal Article
%A Hutterer, Markus
%A Bumes, Elisabeth
%A Riemenschneider, Markus J.
%A Grosse, Jirka
%A Hellwig, Dirk
%A Galldiks, Norbert
%A Langen, Karl-Josef
%A Hau, Peter
%T AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-L-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells
%J Clinical nuclear medicine
%V 42
%N 12
%@ 0363-9762
%C Philadelphia, Pa.
%I Lippincott Williams & Wilkins
%M FZJ-2017-07360
%P e506 - e508
%D 2017
%X We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. 18Ffluoroethyl-L-tyrosine (18F-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of 18F-FET PET mimicking a brain tumor.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29076908
%U <Go to ISI:>//WOS:000415755700005
%R 10.1097/RLU.0000000000001873
%U https://juser.fz-juelich.de/record/838850