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000838850 1001_ $$0P:(DE-HGF)0$$aHutterer, Markus$$b0
000838850 245__ $$aAIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-L-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells
000838850 260__ $$aPhiladelphia, Pa.$$bLippincott Williams & Wilkins$$c2017
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000838850 520__ $$aWe report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. 18Ffluoroethyl-L-tyrosine (18F-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of 18F-FET PET mimicking a brain tumor.
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000838850 7001_ $$0P:(DE-HGF)0$$aBumes, Elisabeth$$b1
000838850 7001_ $$0P:(DE-HGF)0$$aRiemenschneider, Markus J.$$b2
000838850 7001_ $$0P:(DE-HGF)0$$aGrosse, Jirka$$b3
000838850 7001_ $$0P:(DE-HGF)0$$aHellwig, Dirk$$b4
000838850 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b5$$ufzj
000838850 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b6$$ufzj
000838850 7001_ $$0P:(DE-HGF)0$$aHau, Peter$$b7
000838850 773__ $$0PERI:(DE-600)2045053-9$$a10.1097/RLU.0000000000001873$$gVol. 42, no. 12, p. e506 - e508$$n12$$pe506 - e508$$tClinical nuclear medicine$$v42$$x0363-9762$$y2017
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