TY  - JOUR
AU  - Verger, Antoine
AU  - Stegmayr, Carina
AU  - Galldiks, Norbert
AU  - Van Der Gucht, Axel
AU  - Lohmann, Philipp
AU  - Stoffels, Gabriele
AU  - Shah, Nadim J.
AU  - Fink, Gereon R.
AU  - Guedj, Eric
AU  - Langen, Karl-Josef
AU  - Eickhoff, Simon
TI  - Evaluation of factors influencing 18 F-FET uptake in the brain
JO  - NeuroImage: Clinical
VL  - 17
SN  - 2213-1582
CY  - [Amsterdam u.a.]
PB  - Elsevier
M1  - FZJ-2017-07436
SP  - 491–497
PY  - 2018
AB  - PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of 18F-FET uptake in various brain areas, and thus affect quantification of 18F-FET uptake in brain tumours. Negative 18F-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of 18F-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of 18F-FET uptake in the brain. In women, SUVmean of 18F-FET uptake in the brain was 23% higher than in men (p < 0.01). SUVmean of 18F-FET uptake in the brain was positively correlated with BMI (r = 0.29; p < 0.01). The influence of these factors on SUV of 18F-FET was similar in all brain areas. In conclusion, SUV of 18F-FET in the normal brain is influenced by gender and weakly by BMI, but changes are similar in all brain areas.
LB  - PUB:(DE-HGF)16
C6  - pmid:29159062
UR  - <Go to ISI:>//WOS:000426180300053
DO  - DOI:10.1016/j.nicl.2017.11.005
UR  - https://juser.fz-juelich.de/record/838933
ER  -