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@ARTICLE{Verger:838933,
      author       = {Verger, Antoine and Stegmayr, Carina and Galldiks, Norbert
                      and Van Der Gucht, Axel and Lohmann, Philipp and Stoffels,
                      Gabriele and Shah, Nadim J. and Fink, Gereon R. and Guedj,
                      Eric and Langen, Karl-Josef and Eickhoff, Simon},
      title        = {{E}valuation of factors influencing 18 {F}-{FET} uptake in
                      the brain},
      journal      = {NeuroImage: Clinical},
      volume       = {17},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-07436},
      pages        = {491–497},
      year         = {2018},
      abstract     = {PET using the amino-acid O-(2-18F-fluoroethyl)-l-tyrosine
                      (18F-FET) is gaining increasing interest for brain tumour
                      management. Semi-quantitative analysis of tracer uptake in
                      brain tumours is based on the standardized uptake value
                      (SUV) and the tumour-to-brain ratio (TBR). The aim of this
                      study was to explore physiological factors that might
                      influence the relationship of SUV of 18F-FET uptake in
                      various brain areas, and thus affect quantification of
                      18F-FET uptake in brain tumours. Negative 18F-FET PET scans
                      of 107 subjects, showing an inconspicuous brain distribution
                      of 18F-FET, were evaluated retrospectively. Whole-brain
                      quantitative analysis with Statistical Parametric Mapping
                      (SPM) using parametric SUV PET images, and volumes of
                      interest (VOIs) analysis with fronto-parietal, temporal,
                      occipital, and cerebellar SUV background areas were
                      performed to study the effect of age, gender, height,
                      weight, injected activity, body mass index (BMI), and body
                      surface area (BSA). After multivariate analysis, female
                      gender and high BMI were found to be two independent factors
                      associated with increased SUV of 18F-FET uptake in the
                      brain. In women, SUVmean of 18F-FET uptake in the brain was
                      $23\%$ higher than in men (p < 0.01). SUVmean of 18F-FET
                      uptake in the brain was positively correlated with BMI (r =
                      0.29; p < 0.01). The influence of these factors on SUV of
                      18F-FET was similar in all brain areas. In conclusion, SUV
                      of 18F-FET in the normal brain is influenced by gender and
                      weakly by BMI, but changes are similar in all brain areas.},
      cin          = {INM-4 / INM-3 / INM-7 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-7-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29159062},
      UT           = {WOS:000426180300053},
      doi          = {10.1016/j.nicl.2017.11.005},
      url          = {https://juser.fz-juelich.de/record/838933},
}