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@INBOOK{Gross:839912,
      author       = {Blankenburg, S. and Balfanz, S. and Baumann, A. and Blenau,
                      W.},
      editor       = {Gross, Aaron D. and Ozoe, Yoshihisa and Coats, Joel R.},
      title        = {{S}ubunit-{S}pecific {M}odulatory {F}unctions {A}re
                      {C}onserved in an {I}nterspecies {I}nsect {GABA} {B}
                      {R}eceptor {H}eteromer},
      volume       = {1265},
      address      = {Washington, DC},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2017-07490},
      isbn         = {0-8412-3260-1 (print)},
      series       = {ACS Symposium Series},
      pages        = {85 - 107},
      year         = {2017},
      comment      = {Advances in Agrochemicals: Ion Channels and G
                      Protein-Coupled Receptors (GPCRs) as Targets for Pest
                      Control / Gross, Aaron D. (Editor) ; Washington, DC :
                      American Chemical Society, 2017, ; ISSN: 0097-6156=1947-5918
                      ; ISBN: 0-8412-3260-1=0-8412-3258-X ;
                      doi:10.1021/bk-2017-1265},
      booktitle     = {Advances in Agrochemicals: Ion
                       Channels and G Protein-Coupled
                       Receptors (GPCRs) as Targets for Pest
                       Control / Gross, Aaron D. (Editor) ;
                       Washington, DC : American Chemical
                       Society, 2017, ; ISSN:
                       0097-6156=1947-5918 ; ISBN:
                       0-8412-3260-1=0-8412-3258-X ;
                       doi:10.1021/bk-2017-1265},
      abstract     = {GABAB receptors are seven-transmembrane G-protein-coupled
                      receptors (GPCRs) for γ-aminobutyric acid (GABA), the most
                      abundant inhibitory neurotransmitter in the central nervous
                      system. They couple to a variety of signalling pathways and
                      thereby serve diverse functions. In humans, GABAB receptors
                      are implicated in a number of psychiatriac and neurological
                      diseases. GABAB receptors function as obligate heteromers
                      consisting of the two subunits, GB1 and GB2, whereby GB1
                      binds the ligand and GB2 is coupled to the G protein. This
                      unique functional principle is phylogenetically conserved
                      and can be found in both deuterostomes and protostomes.
                      Nevertheless, remarkable differences in the pharmacological
                      properties do exist between species. In this study, we aimed
                      to investigate the functionality and the pharmacological
                      profile of an interspecies GABAB receptor heteromer,
                      consisting of the GB1 subunit from the American cockroach
                      Periplaneta americana and the GB2 subunit of the fruit fly
                      Drosophila melanogaster. Co-expression of both proteins in a
                      heterologous expression system indeed lead to the formation
                      of functional receptor heteromers. Activation of
                      interspecies heterodimers caused a dose-dependent decrease
                      in the production of cAMP. Moreover, we demonstrate that GB2
                      modulates not only the potency but also the efficacy of
                      ligand binding.},
      cin          = {ICS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1021/bk-2017-1265.ch005},
      url          = {https://juser.fz-juelich.de/record/839912},
}